Author, as appears in the article.: Alegret, Josep M; Martinez-Micaelo, Neus; Aragones, Gerard; Beltran-Debon, Raul
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Alegret Colomé, Josep Maria / Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro
Keywords: Wss wall systolic stress Tav tricuspid aortic valve Sele protein, human Platelet endothelial cell adhesion molecule-1 Male Lv left ventricular Humans Heart valve diseases Female Endothelial microparticles Emps endothelial microparticles E-selectin Dilatation Biomarkers Bicuspid aortic valve disease Bicuspid aortic valve Bav bicuspid aortic valve Ascending aorta Aortic valve Aortic root Aortic diseases Aortic dilation Adult Abbreviations avs aortic valve surgery bicuspid aortic valve ascending aorta aortic root aortic dilation
Abstract: Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/¿l, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (¿ = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/¿l, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.
Research group: Unitat de Recerca Biomèdica Grup de Recerca en Nutrigenòmica
Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josepmaria.alegret@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0002-6117-5512 0000-0001-8657-5726 0000-0001-9691-1906
Record's date: 2025-02-17
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: International Journal Of Cardiology. 217 35-41
APA: Alegret, Josep M; Martinez-Micaelo, Neus; Aragones, Gerard; Beltran-Debon, Raul (2016). Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation. International Journal Of Cardiology, 217(), 35-41. DOI: 10.1016/j.ijcard.2016.04.184
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV