Author, as appears in the article.: Alegret JM, Martínez-Micaelo N, Aragonès G, Beltrán-Debón R

Department: Medicina i Cirurgia Bioquímica i Biotecnologia

URV's Author/s: Alegret Colomé, Josep Maria / Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro

Keywords: Wss wall systolic stress Tav tricuspid aortic valve Lv left ventricular Endothelial microparticles Emps endothelial microparticles Bav bicuspid aortic valve Abbreviations avs aortic valve surgery bicuspid aortic valve ascending aorta aortic root aortic dilation

Abstract: Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/¿l, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (¿ = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/¿l, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.

Research group: Unitat de Recerca Biomèdica Grup de Recerca en Nutrigenòmica

Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: gerard.aragones@urv.cat raul.beltran@urv.cat josepmaria.alegret@urv.cat

Author identifier: 0000-0001-9691-1906 0000-0002-6117-5512

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30886-5/abstract#%20

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Cardiology. 217 35-41

APA: Alegret JM, Martínez-Micaelo N, Aragonès G, Beltrán-Debón R (2016). Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation. International Journal Of Cardiology, 217(), 35-41. DOI: 10.1016/j.ijcard.2016.04.184

Article's DOI: 10.1016/j.ijcard.2016.04.184

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications