Articles producció científica> Medicina i Cirurgia

Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation

  • Identification data

    Identifier: imarina:4681235
    Authors:
    Alegret, JMMartínez-Micaelo, NAragonès, GBeltrán-Debón, R
    Abstract:
    Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/¿l, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (¿ = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/¿l, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.
  • Others:

    Author, as appears in the article.: Alegret, JM; Martínez-Micaelo, N; Aragonès, G; Beltrán-Debón, R
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Alegret Colomé, Josep Maria / Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro
    Keywords: Wss wall systolic stress Tav tricuspid aortic valve Lv left ventricular Endothelial microparticles Emps endothelial microparticles Bav bicuspid aortic valve Abbreviations avs aortic valve surgery bicuspid aortic valve ascending aorta aortic root aortic dilation
    Abstract: Background/objectives The mechanisms underlying aortic dilation in bicuspid aortic valve (BAV) disease are unknown. Circulating endothelial microparticles (EMPs) have emerged as biomarkers of endothelial damage. We sought to evaluate the relationships among EMPs, BAV disease, and aortic dilation. Methods Four evaluations were used. Circulating EMPs (PECAM+, E-selectin+) were compared between BAV patients and tricuspid aortic valve (TAV) control subjects. The variables related to circulating EMPs were investigated in BAV patients. Circulating EMP levels were compared between BAV and TAV patients with a dilated aorta. Finally, circulating EMPs in BAV patients were evaluated over time with respect to aortic valve surgery (AVS) or aortic surgery. Results We observed higher levels of circulating PECAM+ EMPs in the BAV patients than in the control subjects (3.98 ± 0.2 vs. 2.39 ± 0.4 per log PECAM+ EMPs/¿l, p = 0.001). Aortic dilation was the most significant variable that correlated with the PECAM+ EMP levels in the BAV patients (¿ = 0.321, p = 0.008). The BAV patients with aortic dilation exhibited higher PECAM+ EMP levels than the TAV patients with dilated aortas, and this correlation was independent of aortic valve function. We observed a drastic decrease in the circulating PECAM+ EMPs following AVS and aortic root replacement (4.27 ± 0.6 and 1.75 ± 0.3 per log PECAM+ EMPs/¿l, p = 0.002). Conclusion The observed pattern of higher circulating PECAM+ EMP levels links BAV disease to endothelial damage and aortic dilation. Circulating PECAM+ EMPs were identified as a biological variable related to aortic dilation in patients with BAV disease.
    Research group: Unitat de Recerca Biomèdica Grup de Recerca en Nutrigenòmica
    Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josepmaria.alegret@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0002-6117-5512 0000-0001-9691-1906
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30886-5/abstract#%20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Cardiology. 217 35-41
    APA: Alegret, JM; Martínez-Micaelo, N; Aragonès, G; Beltrán-Debón, R (2016). Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation. International Journal Of Cardiology, 217(), 35-41. DOI: 10.1016/j.ijcard.2016.04.184
    Article's DOI: 10.1016/j.ijcard.2016.04.184
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Wss wall systolic stress
    Tav tricuspid aortic valve
    Lv left ventricular
    Endothelial microparticles
    Emps endothelial microparticles
    Bav bicuspid aortic valve
    Abbreviations avs aortic valve surgery
    bicuspid aortic valve
    ascending aorta
    aortic root
    aortic dilation
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
    Biodiversidade
    Antropologia / arqueologia
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