Author, as appears in the article.: Prasad Sharma, Raju; Schuhmacher, Marta; Kumar, Vikas;
Department: Enginyeria Química
URV's Author/s: Kumar, Vikas / Schuhmacher Ansuategui, Marta
Keywords: System biology Physiologically-based pharmacokinetic (pbpk) model Pfos Perfluorooctane sulfonate (pfos) Pbpk/pd Neuroendocrine Mirna Bdnf system biology pfos pbpk/pd neuroendocrine bdnf
Abstract: Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model. This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both - the chemicals and - biomolecules, help us to understand the dynamic and steady-state behaviors of molecular pathways under perturbed condition. The objective of this article is to illustrate a system toxicology based approach by developing an integrated PBPK/PD coupled miRNA-BDNF pathway model and to demonstrate its application by taking a case study of the PFOS mediated neurotoxicity. System dynamic involves miRNA-mediated BDNF regulation, which plays an important role in the control of neuronal cell proliferation, differentiation, and survivability.
Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Psicología Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Historia Geociências General medicine Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: vikas.kumar@urv.cat marta.schuhmacher@urv.cat
Author identifier: 0000-0002-9795-5967 0000-0003-4381-2490
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S037842741731161X
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Toxicology Letters. 280 79-91
APA: Prasad Sharma, Raju; Schuhmacher, Marta; Kumar, Vikas; (2017). Developing Integrated PBPK/PD Coupled mechanistic pathway model (miRNA-BDNF): an approach towards System toxicology. Toxicology Letters, 280(), 79-91. DOI: 10.1016/j.toxlet.2017.08.003
Article's DOI: 10.1016/j.toxlet.2017.08.003
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV