Articles producció científica> Ciències Mèdiques Bàsiques

Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.

  • Identification data

    Identifier: imarina:4898659
    Authors:
    Ejarque, MiriamGuerrero-Perez, Fernandode la Morena, NuriaCasajoana, AnnaVirgili, NuriaLopez-Urdiales, RafaelMaymo-Masip, ElsaPujol Gebelli, JordiRuiz de Gordejuela, Amador GarciaPerez-Maraver, ManuelPellitero, SilviaFernandez-Veledo, SoniaVendrell, JoanVilarrasa, Nuria
    Abstract:
    We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = -0.453, p = 0.008), waist circumference (r = -0.494, p = 0.004), plasma insulin (r = -0.466, p = 0.007), and systolic blood pressure (BP) (r = -0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = -0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
  • Others:

    Author, as appears in the article.: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebelli, Jordi; Ruiz de Gordejuela, Amador Garcia; Perez-Maraver, Manuel; Pellitero, Silvia; Fernandez-Veledo, Sonia; Vendrell, Joan; Vilarrasa, Nuria
    Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    URV's Author/s: Fernandez Veledo, Sonia / Maymo Masip, Elsa / Vendrell Ortega, Juan José
    Keywords: Young adult Weight loss Stomach Obesity, morbid Middle aged Male Incretins Humans Good health and well-being Glucagon-like peptide-1 receptor Glp1r protein, human Gastric bypass Gastrectomy Female Fasting Diabetes mellitus, type 2 Blood glucose Bariatric surgery Adult Adolescent Adipose tissue
    Abstract: We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = -0.453, p = 0.008), waist circumference (r = -0.494, p = 0.004), plasma insulin (r = -0.466, p = 0.007), and systolic blood pressure (BP) (r = -0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = -0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20452322
    Author's mail: elsa.maymo@urv.cat sonia.fernandez@urv.cat jvortega@iispv.cat
    Author identifier: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-6994-6115
    Record's date: 2025-02-01
    Paper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Scientific Reports. 9 (1): 6274-6274
    APA: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebe (2019). Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.. Scientific Reports, 9(1), 6274-6274. DOI: 10.1038/s41598-019-42770-1
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Young adult
    Weight loss
    Stomach
    Obesity, morbid
    Middle aged
    Male
    Incretins
    Humans
    Good health and well-being
    Glucagon-like peptide-1 receptor
    Glp1r protein, human
    Gastric bypass
    Gastrectomy
    Female
    Fasting
    Diabetes mellitus, type 2
    Blood glucose
    Bariatric surgery
    Adult
    Adolescent
    Adipose tissue
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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