Author, as appears in the article.: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebelli, Jordi; Ruiz de Gordejuela, Amador Garcia; Perez-Maraver, Manuel; Pellitero, Silvia; Fernandez-Veledo, Sonia; Vendrell, Joan; Vilarrasa, Nuria
Department: Bioquímica i Biotecnologia; Ciències Mèdiques Bàsiques
URV's Author/s: Fernandez Veledo, Sonia / Maymo Masip, Elsa / Vendrell Ortega, Juan José
Keywords: Young adult; Weight loss; Stomach; Obesity, morbid; Middle aged; Male; Incretins; Humans; Good health and well-being; Glucagon-like peptide-1 receptor; Glp1r protein, human; Gastric bypass; Gastrectomy; Female; Fasting; Diabetes mellitus, type 2; Blood glucose; Bariatric surgery; Adult; Adolescent; Adipose tissue
Abstract: We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = -0.453, p = 0.008), waist circumference (r = -0.494, p = 0.004), plasma insulin (r = -0.466, p = 0.007), and systolic blood pressure (BP) (r = -0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = -0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Letras / linguística; Interdisciplinar; Geografía; Geociências; Farmacia; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Biodiversidade; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: elsa.maymo@urv.cat; sonia.fernandez@urv.cat; jvortega@iispv.cat
Record's date: 2025-02-01
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41598-019-42770-1
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Scientific Reports. 9 (1): 6274-6274
APA: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebe (2019). Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.. Scientific Reports, 9(1), 6274-6274. DOI: 10.1038/s41598-019-42770-1
Article's DOI: 10.1038/s41598-019-42770-1
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV