Articles producció científica> Bioquímica i Biotecnologia

Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region

  • Identification data

    Identifier: imarina:5117355
    Authors:
    García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG.
    Abstract:
    Background: Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses. Results: We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of TFBS in the URR might be much broader than thus far described, and different PVs have different repertoires of TFBS. Conclusion: There are common fingerprints in the URR in PVs that infect primates, although the ancestors of these viruses diverged a long time ago. Additionally, there are obvious differences between the URR of alpha and beta PVs, despite these PVs infect similar histological cell types in the same host, i.e. human. A thorough analysis of the TFBS in the URR might provide crucial information about the differential biology of cancer-associated PVs.
  • Others:

    Author, as appears in the article.: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG.
    Department: Bioquímica i Biotecnologia
    e-ISSN: 1471-2148
    URV's Author/s: Garcia Vallve, Santiago
    Keywords: Type-18 promoter Multiple sequence alignment Lineages Life Keratinocytes Enhancer Cervical-cancer worldwide Cell-specific transcription
    Abstract: Background: Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses. Results: We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of TFBS in the URR might be much broader than thus far described, and different PVs have different repertoires of TFBS. Conclusion: There are common fingerprints in the URR in PVs that infect primates, although the ancestors of these viruses diverged a long time ago. Additionally, there are obvious differences between the URR of alpha and beta PVs, despite these PVs infect similar histological cell types in the same host, i.e. human. A thorough analysis of the TFBS in the URR might provide crucial information about the differential biology of cancer-associated PVs.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Medicina veterinaria Medicina i Interdisciplinar Geociências Genetics & heredity Evolutionary biology Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: santi.garcia-vallve@urv.cat
    Author identifier: 0000-0002-0348-7497
    Record's date: 2023-02-18
    Journal volume: 6
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcecolevol.biomedcentral.com/articles/10.1186/1471-2148-6-20
    Papper original source: Bmc Evolutionary Biology. 6
    APA: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG. (2006). Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region. Bmc Evolutionary Biology, 6(), -. DOI: 10.1186/1471-2148-6-20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1186/1471-2148-6-20
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2006
    Publication Type: Journal Publications
  • Keywords:

    Ecology, Evolution, Behavior and Systematics,Evolutionary Biology,Genetics & Heredity
    Type-18 promoter
    Multiple sequence alignment
    Lineages
    Life
    Keratinocytes
    Enhancer
    Cervical-cancer worldwide
    Cell-specific transcription
    Zootecnia / recursos pesqueiros
    Química
    Medicina veterinaria
    Medicina i
    Interdisciplinar
    Geociências
    Genetics & heredity
    Evolutionary biology
    Ecology, evolution, behavior and systematics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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