Author, as appears in the article.: Izaguirre, M.F.; Garcia, N.; Miranda, L.A.; Tomàs, J.; Casco, V.H.
Department: Ciències Mèdiques Bàsiques
e-ISSN: 1678-4375
URV's Author/s: Tomás Ferré, José Maria
Abstract: Cell adhesion molecules act as signal transducers from the extracellular environment to the cytoskeleton and the nucleus and consequently induce changes in the expression pattern of structural proteins. In this study, we showed the effect of thyroid hormone (TH) inhibition and arrest of metamorphosis on the expression of E-cadherin, β-and α-catenin in the developing kidney of Bufo arenarum. Cell adhesion molecules have selective temporal and spatial expression during development suggesting a specific role in nephrogenesis. In order to study mechanisms controlling the expression of adhesion molecules during renal development, we blocked the B. arenarum metamorphosis with a goitrogenic substance that blocks TH synthesis. E-cadherin expression in the proximal tubules is independent of thyroid control. However, the blockage of TH synthesis causes up-regulation of E-cadherin in the collecting ducts, the distal tubules and the glomeruli. The expression of β-and α-catenin in the collecting ducts, the distal tubules, the glomeruli and the mesonephric mesenchyme is independent of TH. TH blockage causes up-regulation of β-and α-catenin in the proximal tubules. In contrast to E-cadherin, the expression of the desmosomal cadherin desmoglein 1 (Dsg-1) is absent in the control of the larvae kidney during metamorphosis and is expressed in some interstitial cells in the KClO4 treated larvae. According to this work, the Dsg-1 expression is down-regulated by TH. We demonstrated that the expression of E-cadherin, Dsg-1, β-catenin and α-catenin are differentially affected by TH levels, suggesting a hormone-dependent role of these proteins in the B. arenarum renal metamorphosis.
Thematic Areas: Zootecnia / recursos pesqueiros Sociología Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências General agricultural and biological sciences Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Economia Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biology Biodiversidade Astronomia / física Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all) Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1519-6984
Author's mail: josepmaria.tomas@urv.cat
Author identifier: 0000-0002-0406-0006
Last page: 569
Record's date: 2023-04-15
Journal volume: 68
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000300014&lng=en&tlng=en
Papper original source: Brazilian Journal Of Biology. 68 (3): 631-637
APA: Izaguirre, M.F.; Garcia, N.; Miranda, L.A.; Tomàs, J.; Casco, V.H. (2008). Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae). Brazilian Journal Of Biology, 68(3), 631-637. DOI: 10.1590/S1519-69842008000300014
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1590/S1519-69842008000300014
Entity: Universitat Rovira i Virgili
Journal publication year: 2008
First page: 561
Publication Type: Journal Publications