Author, as appears in the article.: Pfaller M; Espinel-Ingroff A; Bustamante B; Canton E; Diekema D; Fothergill A; Fuller J; Gonzalez G; Guarro J; Lass-Flörl C; Lockhart S; Martin-Mazuelos E; Meis J; Ostrosky-Zeichner L; Pelaez T; St-Germain G; Turnidge J
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Guarro Artigas, Josep
Keywords: Surveillance Statistical-methods Spp. Population Management Escmid-asterisk guideline Echinocandins Caspofungin Breakpoints Aspergillus
Abstract: Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for Candida spp. and the echinocandins, we established ECVs for anidulafungin and micafungin on the basis of wild-type (WT) MIC distributions (for organisms in a species-drug combination with no detectable acquired resistance mechanisms) for 8,210 Candida albicans, 3,102 C. glabrata, 3,976 C. parapsilosis, 2,042 C. tropicalis, 617 C. krusei, 258 C. lusitaniae, 234 C. guilliermondii, and 131 C. dubliniensis isolates. CLSI broth microdilution MIC data gathered from 15 different laboratories in Canada, Europe, Mexico, Peru, and the United States were aggregated to statistically define ECVs. ECVs encompassing 97.5% of the statistically modeled population for anidulafungin and micafungin were, respectively, 0.12 and 0.03 μg/ml for C. albicans, 0.12 and 0.03 μg/ml for C. glabrata, 8 and 4 μg/ml for C. parapsilosis, 0.12 and 0.06 μg/ml for C. tropicalis, 0.25 and 0.25 μg/ml for C. krusei, 1 and 0.5 μg/ml for C. lusitaniae, 8 and 2 μg/ml for C. guilliermondii, and 0.12 and 0.12 μg/ml for C. dubliniensis. Previously reported single and multicenter ECVs defined in the present study were quite similar or within 1 2-fold dilution of each other. For a collection of 230 WT isolates (no fks mutations) and 51 isolates with fks mutations, the species-specific ECVs for anidulafungin and micafungin correctly classified 47 (92.2%) and 51 (100%) of the fks mutants, respectively, as non-WT strains. These ECVs may aid in detecting non-WT isolates with reduced susceptibility to anidulafungin and micafungin due to fks mutations.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josep.guarro@urv.cat
Author identifier: 0000-0002-7839-7568
Record's date: 2024-07-20
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.asm.org/doi/10.1128/aac.02020-13
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antimicrobial Agents And Chemotherapy. 58 (2): 916-922
APA: Pfaller M; Espinel-Ingroff A; Bustamante B; Canton E; Diekema D; Fothergill A; Fuller J; Gonzalez G; Guarro J; Lass-Flörl C; Lockhart S; Martin-Mazuel (2014). Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight candida species and the CLSI M27-A3 broth microdilution method. Antimicrobial Agents And Chemotherapy, 58(2), 916-922. DOI: 10.1128/AAC.02020-13
Article's DOI: 10.1128/AAC.02020-13
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications