Author, as appears in the article.: Serena, Carolina; Calvo, Enrique; Paz Clares, Mari; Luisa Diaz, Mara; Chicote, Javier U.; Beltran-Debon, Raul; Fontova, Ramon; Rodriguez, Alejandro; Garcia-Espana, Enrique; Garcia-Espana, Antonio;
Department: Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Beltrán Debón, Raúl Alejandro / Calvo Manso, Enrique / Fontova Garrofé, Ramon / Rodríguez Oviedo, Alejandro Hugo / Serena Perelló, Carolina
Abstract: Background: The clinical use of purified SOD enzymes has strong limitations due to their large molecular size, high production cost and immunogenicity. These limitations could be compensated by using instead synthetic SOD mimetic compounds of low molecular weight. Background/Methodology: We have recently reported that two SOD mimetic compounds, the MnII complexes of the polyamines Pytren2Q and Pytren4Q, displayed high antioxidant activity in bacteria and yeast. Since frequently molecules with antioxidant properties or free-radical scavengers also have anti-inflammatory properties we have assessed the anti-inflammatory potential of Pytren2Q and Pytren4Q MnII complexes, in cultured macrophages and in a murine model of inflammation, by measuring the degree of protection they could provide against the cellular injury produced by lipopolisacharide, a bacterial endotoxin. Principal Findings: In this report we show that the MnII complex of Pytren4Q but not that of Pytren2Q effectively protected human cultured THP-1 macrophages and whole mice from the inflammatory effects produced by LPS. These results obtained with two molecules that are isomers highlight the importance of gathering experimental data from animal models of disease in assessing the potential of candidate molecules. Conclusion/Significance: The effective anti-inflammatory activity of the MnII complex of Pytren4Q in addition to its low toxicity, water solubility and ease of production would suggest it is worth taking into consideration for future pharmacological studies © 2015 Serena et al.
Thematic Areas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: alejandrohugo.rodriguez@urv.cat ramon.fontova@urv.cat carolina.serena@urv.cat enrique.calvo@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0001-8828-5984 0000-0001-9691-1906
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119102
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Plos One. 10 (3): e0119102-
APA: Serena, Carolina; Calvo, Enrique; Paz Clares, Mari; Luisa Diaz, Mara; Chicote, Javier U.; Beltran-Debon, Raul; Fontova, Ramon; Rodriguez, Alejandro; G (2015). Significant in vivo anti-inflammatory activity of pytren4Q-Mn α superoxide dismutase 2 (SOD2) mimetic scorpiand-like Mn (II) complex. Plos One, 10(3), e0119102-. DOI: 10.1371/journal.pone.0119102
Article's DOI: 10.1371/journal.pone.0119102
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications