Articles producció científica> Bioquímica i Biotecnologia

Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide. [Review of the advances in treatment for Alzheimer disease: Strategies for combating β-amyloid protein].

  • Identification data

    Identifier: imarina:5129102
    Authors:
    Folch, JEttcheto, MPetrov, DAbad, SPedros, IMarin, MOlloquequi, JCamins, A
    Abstract:
    Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence and the socioeconomic burden associated with the disease pose major challenges for public health in the 21st century. In this review we focus on both existing treatments and the therapies being developed, which principally target the β-amyloid protein. DISCUSSION: The amyloidogenic hypothesis proposes that β-amyloid plays a key role in AD. Several pharmacological approaches aim to reduce the formation of β-amyloid peptides by inhibiting the β-secretase and γ-secretase enzymes. In addition, both passive and active immunotherapies have been developed for the purpose of inhibiting β-amyloid peptide aggregation. CONCLUSIONS: Progress in identifying the molecular basis of AD may provide better models for understanding the causes of this neurodegenerative disease. The lack of efficacy of solanezumab (a humanised monoclonal antibody that promotes β-amyloid clearance in the brain), demonstrated by 2 recent Phase III clinical trials in patients with mild AD, suggests that the amyloidogenic hypothesis needs to be revised.
  • Others:

    Author, as appears in the article.: Folch, J; Ettcheto, M; Petrov, D; Abad, S; Pedros, I; Marin, M; Olloquequi, J; Camins, A
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Folch Lopez, Jaume
    Keywords: Solanezumab Humans Hipótesis amiloidea Gamma-secretase Gamma-secretasa Beta-secretase Beta-secretasa Beta-amyloid Beta-amiloide App protein, human Antibodies, monoclonal, humanized Amyloid precursor protein secretases Amyloid hypotheses Amyloid beta-protein precursor Amyloid beta-peptides Alzheimer disease Alzheimer gamma-secretase gamma-secretasa beta-secretase beta-secretasa beta-amyloid beta-amiloide amyloid hypotheses alzheimer disease alzheimer
    Abstract: Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence and the socioeconomic burden associated with the disease pose major challenges for public health in the 21st century. In this review we focus on both existing treatments and the therapies being developed, which principally target the β-amyloid protein. DISCUSSION: The amyloidogenic hypothesis proposes that β-amyloid plays a key role in AD. Several pharmacological approaches aim to reduce the formation of β-amyloid peptides by inhibiting the β-secretase and γ-secretase enzymes. In addition, both passive and active immunotherapies have been developed for the purpose of inhibiting β-amyloid peptide aggregation. CONCLUSIONS: Progress in identifying the molecular basis of AD may provide better models for understanding the causes of this neurodegenerative disease. The lack of efficacy of solanezumab (a humanised monoclonal antibody that promotes β-amyloid clearance in the brain), demonstrated by 2 recent Phase III clinical trials in patients with mild AD, suggests that the amyloidogenic hypothesis needs to be revised.
    Thematic Areas: Psicología Neurology (clinical) Medicine (miscellaneous) Medicina ii Medicina i General medicine Clinical neurology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15781968
    Author's mail: jaume.folch@urv.cat
    Author identifier: 0000-0002-5051-8858
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S021348531500064X?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Neurologia. 33 (1): 47-58
    APA: Folch, J; Ettcheto, M; Petrov, D; Abad, S; Pedros, I; Marin, M; Olloquequi, J; Camins, A (2018). Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide. [Review of the advances in treatment for Alzheimer disease: Strategies for combating β-amyloid protein].. Neurologia, 33(1), 47-58. DOI: 10.1016/j.nrl.2015.03.012
    Article's DOI: 10.1016/j.nrl.2015.03.012
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Clinical Neurology,Medicine (Miscellaneous),Neurology (Clinical)
    Solanezumab
    Humans
    Hipótesis amiloidea
    Gamma-secretase
    Gamma-secretasa
    Beta-secretase
    Beta-secretasa
    Beta-amyloid
    Beta-amiloide
    App protein, human
    Antibodies, monoclonal, humanized
    Amyloid precursor protein secretases
    Amyloid hypotheses
    Amyloid beta-protein precursor
    Amyloid beta-peptides
    Alzheimer disease
    Alzheimer
    gamma-secretase
    gamma-secretasa
    beta-secretase
    beta-secretasa
    beta-amyloid
    beta-amiloide
    amyloid hypotheses
    alzheimer disease
    alzheimer
    Psicología
    Neurology (clinical)
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    General medicine
    Clinical neurology
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