Author, as appears in the article.: Bladé C, Aragonès G, Arola-Arnal A, Muguerza B, Bravo FI, Salvadó MJ, Arola L, Suárez M.
Department: Bioquímica i Biotecnologia
URV's Author/s: Aragonès Bargalló, Gerard / Arola Arnal, Anna / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Salvadó Rovira, Maria Josepa / Suárez Recio, Manuel
Keywords: Polyphenols Molecular mechanisms Microbiota Metabolic diseases Flavonoids Circadian rhythms molecular mechanisms microbiota metabolic diseases flavonoids circadian rhythms
Abstract: © 2016 International Union of Biochemistry and Molecular Biology. Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several epidemiological studies connect PA consumption and health benefits and the designation of PAs as healthy compounds started at the early stages of the 20th century. The beneficial health properties of PAs are attributed to their conjugated and colonic metabolites. Therefore, gut microbial compositions can determine the effectiveness of PAs. Reciprocally, dietary polyphenols can act as prebiotics. Recently, it has also been described that PAs modulate the circadian rhythm. Biochemical and epigenetic mechanisms, including the modulation of microRNAs, allow PAs to modulate cell functionality. PA effects in metabolic diseases are also reviewed.
Thematic Areas: Saúde coletiva Química Molecular medicine Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Farmacia Enfermagem Endocrinology & metabolism Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: manuel.suarez@urv.cat franciscaisabel.bravo@urv.cat anna.arola@urv.cat gerard.aragones@urv.cat lluis.arola@urv.cat begona.muguerza@urv.cat
Author identifier: 0000-0003-0122-8253 0000-0002-6468-3088 0000-0001-6529-1345 0000-0003-2767-1974 0000-0001-7384-8588
Record's date: 2024-09-14
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.1249
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Biofactors. 42 (1): 5-12
APA: Bladé C, Aragonès G, Arola-Arnal A, Muguerza B, Bravo FI, Salvadó MJ, Arola L, Suárez M. (2016). Proanthocyanidins in health and disease. Biofactors, 42(1), 5-12. DOI: 10.1002/biof.1249
Article's DOI: 10.1002/biof.1249
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV