Author, as appears in the article.: Bladé C, Aragonès G, Arola-Arnal A, Muguerza B, Bravo FI, Salvadó MJ, Arola L, Suárez M.

Department: Bioquímica i Biotecnologia

URV's Author/s: Aragonès Bargalló, Gerard / Arola Arnal, Anna / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Salvadó Rovira, Maria Josepa / Suárez Recio, Manuel

Keywords: Polyphenols Molecular mechanisms Microbiota Metabolic diseases Flavonoids Circadian rhythms molecular mechanisms microbiota metabolic diseases flavonoids circadian rhythms

Abstract: © 2016 International Union of Biochemistry and Molecular Biology. Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several epidemiological studies connect PA consumption and health benefits and the designation of PAs as healthy compounds started at the early stages of the 20th century. The beneficial health properties of PAs are attributed to their conjugated and colonic metabolites. Therefore, gut microbial compositions can determine the effectiveness of PAs. Reciprocally, dietary polyphenols can act as prebiotics. Recently, it has also been described that PAs modulate the circadian rhythm. Biochemical and epigenetic mechanisms, including the modulation of microRNAs, allow PAs to modulate cell functionality. PA effects in metabolic diseases are also reviewed.

Thematic Areas: Saúde coletiva Química Molecular medicine Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Farmacia Enfermagem Endocrinology & metabolism Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: gerard.aragones@urv.cat franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat mariajosepa.salvado@urv.cat anna.arola@urv.cat manuel.suarez@urv.cat

Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0003-2767-1974 0000-0003-3883-3326 0000-0001-6529-1345 0000-0003-0122-8253

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/submittedVersion

Link to the original source: https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.1249

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Biofactors. 42 (1): 5-12

APA: Bladé C, Aragonès G, Arola-Arnal A, Muguerza B, Bravo FI, Salvadó MJ, Arola L, Suárez M. (2016). Proanthocyanidins in health and disease. Biofactors, 42(1), 5-12. DOI: 10.1002/biof.1249

Article's DOI: 10.1002/biof.1249

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications