Articles producció científica> Bioquímica i Biotecnologia

Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome

  • Identification data

    Identifier: imarina:5129584
    Authors:
    Mora-Cubillos, XimenaTulipani, SaraGarcia-Aloy, MarBullo, MonicaTinahones, Francisco JAndres-Lacueva, Cristina
    Abstract:
    To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • Others:

    Author, as appears in the article.: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica
    Keywords: Prevention Plasma human Metabolomics Medium-chain Mediterranean diet Intervention Health Gut microbiota Ellagic acid Dicarboxylic-acids Consumption Cardiovascular-disease Biomarkers of nuts Adiposity metabolomics gut microbiota biomarkers of nuts adiposity
    Abstract: To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat
    Author identifier: 0000-0002-0218-7046
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201500549
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Molecular Nutrition & Food Research. 59 (12): 2480-2490
    APA: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina (2015). Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Molecular Nutrition & Food Research, 59(12), 2480-2490. DOI: 10.1002/mnfr.201500549
    Article's DOI: 10.1002/mnfr.201500549
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Prevention
    Plasma human
    Metabolomics
    Medium-chain
    Mediterranean diet
    Intervention
    Health
    Gut microbiota
    Ellagic acid
    Dicarboxylic-acids
    Consumption
    Cardiovascular-disease
    Biomarkers of nuts
    Adiposity
    metabolomics
    gut microbiota
    biomarkers of nuts
    adiposity
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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