Author, as appears in the article.: Paredes K; Capilla J; Mayayo E; Guarro J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / Paredes Aguilar, Katihuska Viviana

Abstract: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Author's mail: kathiuska.paredes@urv.cat josep.guarro@urv.cat emilio.mayayo@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0001-9078-3800 0000-0002-7839-7568 0000-0003-4485-3809 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://aac.asm.org/content/60/4/2063

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Antimicrobial Agents And Chemotherapy. 60 (4): 2063-2068

APA: Paredes K; Capilla J; Mayayo E; Guarro J (2016). Virulence and resistance to antifungal therapies of Scopulariopsis species. Antimicrobial Agents And Chemotherapy, 60(4), 2063-2068. DOI: 10.1128/AAC.02275-15

Article's DOI: 10.1128/AAC.02275-15

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications