Articles producció científica> Medicina i Cirurgia

Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial

  • Identification data

    Identifier: imarina:5129697
    Authors:
    Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J.
    Abstract:
    Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.
  • Others:

    Author, as appears in the article.: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J.
    Department: Medicina i Cirurgia
    URV's Author/s: Closa Monasterolo, Ricardo / Collell Hernández, Rosa Maria / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
    Keywords: Weight-gain Pressure Obesity Malnutrition Left-ventricular mass Impact Igf-i Heart-disease Growth-factor-i Childhood
    Abstract: Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.
    Thematic Areas: Serviço social Saúde coletiva Química Pediatrics, perinatology and child health Pediatrics Medicina ii Medicina i Interdisciplinar Ensino Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: veronica.luque@urv.cat rosamaria.collell@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Author identifier: 0000-0003-2615-8175 0000-0002-4985-4272 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.nature.com/articles/pr201630
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Pediatric Research. 79 (6): 880-888
    APA: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J. (2016). Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial. Pediatric Research, 79(6), 880-888. DOI: 10.1038/pr.2016.30
    Article's DOI: 10.1038/pr.2016.30
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Pediatrics,Pediatrics, Perinatology and Child Health
    Weight-gain
    Pressure
    Obesity
    Malnutrition
    Left-ventricular mass
    Impact
    Igf-i
    Heart-disease
    Growth-factor-i
    Childhood
    Serviço social
    Saúde coletiva
    Química
    Pediatrics, perinatology and child health
    Pediatrics
    Medicina ii
    Medicina i
    Interdisciplinar
    Ensino
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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