Author, as appears in the article.: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J.

Department: Medicina i Cirurgia

URV's Author/s: Closa Monasterolo, Ricardo / Collell Hernández, Rosa Maria / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica

Keywords: Weight-gain Pressure Obesity Malnutrition Left-ventricular mass Impact Igf-i Heart-disease Growth-factor-i Childhood

Abstract: Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.

Thematic Areas: Serviço social Saúde coletiva Química Pediatrics, perinatology and child health Pediatrics Medicina ii Medicina i Interdisciplinar Ensino Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: rosamaria.collell@urv.cat veronica.luque@urv.cat joaquin.escribano@urv.cat natalia.ferre@urv.cat ricardo.closa@urv.cat

Author identifier: 0000-0002-4985-4272 0000-0003-2615-8175 0000-0002-5041-459X 0000-0002-2838-1525 0000-0002-9963-4163

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.nature.com/articles/pr201630

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Pediatric Research. 79 (6): 880-888

APA: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J. (2016). Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial. Pediatric Research, 79(6), 880-888. DOI: 10.1038/pr.2016.30

Article's DOI: 10.1038/pr.2016.30

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications