Author, as appears in the article.: Collell, Rosa; Closa-Monasterolo, Ricardo; Ferre, Natalia; Luque, Veronica; Koletzko, Berthold; Grote, Veit; Janas, Roman; Verduci, Elvira; Escribano, Joaquin
Department: Medicina i Cirurgia
URV's Author/s: Closa Monasterolo, Ricardo / Collell Hernández, Rosa Maria / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Gispert Llauradó, Mariona / Luque Moreno, Verònica
Keywords: Weight-gain Time factors Spain Sex factors Pressure Pediatric obesity Obesity Malnutrition Male Left-ventricular mass Insulin-like growth factor i Infant, newborn Infant nutritional physiological phenomena Infant formula Infant Impact Igf-i Humans Heart-disease Heart function tests Heart Growth-factor-i Female Energy intake Echocardiography, doppler Echocardiography Dietary proteins Diet Cohort studies Clinical trials as topic Childhood Child Breast feeding Body weight Blood pressure Anthropometry
Abstract: Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.
Thematic Areas: Serviço social Saúde coletiva Química Pediatrics, perinatology and child health Pediatrics Medicina ii Medicina i Interdisciplinar Ensino Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.luque@urv.cat rosamaria.collell@urv.cat mariona.gispert@iispv.cat mariona.gispert@iispv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
Author identifier: 0000-0003-2615-8175 0000-0002-4985-4272 0000-0002-4586-8079 0000-0002-4586-8079 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Pediatric Research. 79 (6): 880-888
APA: Collell, Rosa; Closa-Monasterolo, Ricardo; Ferre, Natalia; Luque, Veronica; Koletzko, Berthold; Grote, Veit; Janas, Roman; Verduci, Elvira; Escribano, (2016). Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial. Pediatric Research, 79(6), 880-888. DOI: 10.1038/pr.2016.30
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV