Articles producció científica> Ciències Mèdiques Bàsiques

Age-related effects of X-ray irradiation on mouse hippocampus

  • Identification data

    Identifier: imarina:5129815
    Authors:
    Casciati ADobos KAntonelli FBenedek AKempf SJBellés MBalogh ATanori MHeredia LAtkinson MJvon Toerne CAzimzadeh OSaran ASáfrány GBenotmane MALinares-Vidal MVTapio SLumniczky KPazzaglia S
    Abstract:
    Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.
  • Others:

    Author, as appears in the article.: Casciati A; Dobos K; Antonelli F; Benedek A; Kempf SJ; Bellés M; Balogh A; Tanori M; Heredia L; Atkinson MJ; von Toerne C; Azimzadeh O; Saran A; Sáfrány G; Benotmane MA; Linares-Vidal MV; Tapio S; Lumniczky K; Pazzaglia S
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Bellés Mateu, Montserrat / Heredia Santaella, Luis / Linares Vidal, M. Victoria
    Keywords: cognitive effects hippocampal neurogenesis mitochondria proteomics Cognitive effects Hippocampal neurogenesis Mitochondria Proteomics Radiation
    Abstract: Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.
    Thematic Areas: Administração pública e de empresas, ciências contábeis e turismo Astronomia / física Biodiversidade Biotecnología Cell biology Ciência da computação Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Engenharias ii Farmacia Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Odontología Oncology Química Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: mvictoria.linares@urv.cat montserrat.belles@urv.cat luis.heredia@urv.cat
    ISSN: 19492553
    Author identifier: 0000-0003-4170-4197 0000-0002-9282-2989 0000-0001-9330-9418
    Record's date: 2023-03-05
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.oncotarget.com/article/8575/text/
    Papper original source: Oncotarget. 7 (19): 28040-58
    APA: Casciati A; Dobos K; Antonelli F; Benedek A; Kempf SJ; Bellés M; Balogh A; Tanori M; Heredia L; Atkinson MJ; von Toerne C; Azimzadeh O; Saran A; Sáfrá (2016). Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget, 7(19), 28040-58. DOI: 10.18632/oncotarget.8575
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.18632/oncotarget.8575
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Cell Biology,Oncology
    cognitive effects
    hippocampal neurogenesis
    mitochondria
    proteomics
    Cognitive effects
    Hippocampal neurogenesis
    Mitochondria
    Proteomics
    Radiation
    Administração pública e de empresas, ciências contábeis e turismo
    Astronomia / física
    Biodiversidade
    Biotecnología
    Cell biology
    Ciência da computação
    Ciência de alimentos
    Ciências agrárias i
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Educação física
    Engenharias ii
    Farmacia
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Nutrição
    Odontología
    Oncology
    Química
    Zootecnia / recursos pesqueiros
    19492553
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