Articles producció científica> Ciències Mèdiques Bàsiques

Maternal folate status and the BHMT c.716g>A polymorphism affect the betaine dimethylglycine pathway during pregnancy

  • Identification data

    Identifier: imarina:5130359
    Authors:
    Colomina J, Cavallé-Busquets P, Fernàndez-Roig S, Solé-Navais P, Fernandez-Ballart J, Ballesteros M, Ueland P, Meyer K, Murphy M
    Abstract:
    The effect of the betaine: homocysteine methyltransferase BHMT c.716G>A (G: guanosine; A: adenosine) single nucleotide polymorphism (SNP) on the BHMT pathway is unknown during pregnancy. We hypothesised that it impairs betaine to dimethylglycine conversion and that folate status modifies its effect. We studied 612 women from the Reus Tarragona Birth Cohort from ¿12 gestational weeks (GW) throughout pregnancy. The frequency of the variant BHMT c.716A allele was 30.8% (95% confidence interval (CI): 28.3, 33.5). In participants with normal-high plasma folate status (>13.4 nmol/L), least square geometric mean [95% CI] plasma dimethylglycine (pDMG, µmol/L) was lower in the GA (2.35 [2.23, 2.47]) versus GG (2.58 [2.46, 2.70]) genotype at ¿12 GW (p < 0.05) and in the GA (2.08 [1.97, 2.19]) and AA (1.94 [1.75, 2.16]) versus GG (2.29 [2.18, 2.40]) genotypes at 15 GW (p < 0.05). No differences in pDMG between genotypes were observed in participants with possible folate deficiency (¿13.4 µmol/L) (p for interactions at ¿12 GW: 0.023 and 15 GW: 0.038). PDMG was lower in participants with the AA versus GG genotype at 34 GW (2.01 [1.79, 2.25] versus 2.44 [2.16, 2.76] and at labour, 2.51 [2.39, 2.64] versus 3.00 [2.84, 3.18], (p < 0.01)). Possible deficiency compared to normal-high folate status was associated with higher pDMG in multiple linear regression analysis (¿ coefficients [SEM] ranging from 0.07 [0.04], p < 0.05 to 0.20 [0.04], p < 0.001 in models from early and mid-late pregnancy) and the AA compared to GG genotype was associated with lower pDMG (¿ coefficients [SEM] ranging from -0.11 [0.06], p = 0.055 to -0.23 [0.06], p < 0.001). Conclusion: During pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.
  • Others:

    Author, as appears in the article.: Colomina J, Cavallé-Busquets P, Fernàndez-Roig S, Solé-Navais P, Fernandez-Ballart J, Ballesteros M, Ueland P, Meyer K, Murphy M
    Department: Ciències Mèdiques Bàsiques
    e-ISSN: 2072-6643
    URV's Author/s: Fernández Ballart, Joan Domènech / Murphy, Michelle
    Keywords: Synthase Risk Pregnancy Plasma homocysteine Methionine metabolism Mammals Homocysteine methyltransferase Gene-expression Folic-acid supplementation Folate Down-syndrome Dimethylglycine Bhmt c.716g>a Bhmt c.716g > a Betaine: homocysteine methyltransferase Betaine Association folate bhmt c.716g> dimethylglycine betaine: homocysteine methyltransferase betaine a
    Abstract: The effect of the betaine: homocysteine methyltransferase BHMT c.716G>A (G: guanosine; A: adenosine) single nucleotide polymorphism (SNP) on the BHMT pathway is unknown during pregnancy. We hypothesised that it impairs betaine to dimethylglycine conversion and that folate status modifies its effect. We studied 612 women from the Reus Tarragona Birth Cohort from ¿12 gestational weeks (GW) throughout pregnancy. The frequency of the variant BHMT c.716A allele was 30.8% (95% confidence interval (CI): 28.3, 33.5). In participants with normal-high plasma folate status (>13.4 nmol/L), least square geometric mean [95% CI] plasma dimethylglycine (pDMG, µmol/L) was lower in the GA (2.35 [2.23, 2.47]) versus GG (2.58 [2.46, 2.70]) genotype at ¿12 GW (p < 0.05) and in the GA (2.08 [1.97, 2.19]) and AA (1.94 [1.75, 2.16]) versus GG (2.29 [2.18, 2.40]) genotypes at 15 GW (p < 0.05). No differences in pDMG between genotypes were observed in participants with possible folate deficiency (¿13.4 µmol/L) (p for interactions at ¿12 GW: 0.023 and 15 GW: 0.038). PDMG was lower in participants with the AA versus GG genotype at 34 GW (2.01 [1.79, 2.25] versus 2.44 [2.16, 2.76] and at labour, 2.51 [2.39, 2.64] versus 3.00 [2.84, 3.18], (p < 0.01)). Possible deficiency compared to normal-high folate status was associated with higher pDMG in multiple linear regression analysis (¿ coefficients [SEM] ranging from 0.07 [0.04], p < 0.05 to 0.20 [0.04], p < 0.001 in models from early and mid-late pregnancy) and the AA compared to GG genotype was associated with lower pDMG (¿ coefficients [SEM] ranging from -0.11 [0.06], p = 0.055 to -0.23 [0.06], p < 0.001). Conclusion: During pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Author's mail: michelle.murphy@urv.cat
    Author identifier: 0000-0002-6304-6204
    Record's date: 2024-09-07
    Journal volume: 8
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/8/10/621
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 8 (10):
    APA: Colomina J, Cavallé-Busquets P, Fernàndez-Roig S, Solé-Navais P, Fernandez-Ballart J, Ballesteros M, Ueland P, Meyer K, Murphy M (2016). Maternal folate status and the BHMT c.716g>A polymorphism affect the betaine dimethylglycine pathway during pregnancy. Nutrients, 8(10), -. DOI: 10.3390/nu8100621
    Article's DOI: 10.3390/nu8100621
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Synthase
    Risk
    Pregnancy
    Plasma homocysteine
    Methionine metabolism
    Mammals
    Homocysteine methyltransferase
    Gene-expression
    Folic-acid supplementation
    Folate
    Down-syndrome
    Dimethylglycine
    Bhmt c.716g>a
    Bhmt c.716g > a
    Betaine: homocysteine methyltransferase
    Betaine
    Association
    folate
    bhmt c.716g> dimethylglycine
    betaine: homocysteine methyltransferase
    betaine
    a
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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