Author, as appears in the article.: Colomina J, Cavallé-Busquets P, Fernàndez-Roig S, Solé-Navais P, Fernandez-Ballart J, Ballesteros M, Ueland P, Meyer K, Murphy M
Department: Ciències Mèdiques Bàsiques
e-ISSN: 2072-6643
URV's Author/s: Fernández Ballart, Joan Domènech / Murphy, Michelle
Keywords: a betaine betaine: homocysteine methyltransferase bhmt c.716g> dimethylglycine folate Association Betaine Betaine: homocysteine methyltransferase Bhmt c.716g > a Bhmt c.716g>a Dimethylglycine Down-syndrome Folate Folic-acid supplementation Gene-expression Homocysteine methyltransferase Mammals Methionine metabolism Plasma homocysteine Pregnancy Risk Synthase
Abstract: The effect of the betaine: homocysteine methyltransferase BHMT c.716G>A (G: guanosine; A: adenosine) single nucleotide polymorphism (SNP) on the BHMT pathway is unknown during pregnancy. We hypothesised that it impairs betaine to dimethylglycine conversion and that folate status modifies its effect. We studied 612 women from the Reus Tarragona Birth Cohort from ¿12 gestational weeks (GW) throughout pregnancy. The frequency of the variant BHMT c.716A allele was 30.8% (95% confidence interval (CI): 28.3, 33.5). In participants with normal-high plasma folate status (>13.4 nmol/L), least square geometric mean [95% CI] plasma dimethylglycine (pDMG, µmol/L) was lower in the GA (2.35 [2.23, 2.47]) versus GG (2.58 [2.46, 2.70]) genotype at ¿12 GW (p < 0.05) and in the GA (2.08 [1.97, 2.19]) and AA (1.94 [1.75, 2.16]) versus GG (2.29 [2.18, 2.40]) genotypes at 15 GW (p < 0.05). No differences in pDMG between genotypes were observed in participants with possible folate deficiency (¿13.4 µmol/L) (p for interactions at ¿12 GW: 0.023 and 15 GW: 0.038). PDMG was lower in participants with the AA versus GG genotype at 34 GW (2.01 [1.79, 2.25] versus 2.44 [2.16, 2.76] and at labour, 2.51 [2.39, 2.64] versus 3.00 [2.84, 3.18], (p < 0.01)). Possible deficiency compared to normal-high folate status was associated with higher pDMG in multiple linear regression analysis (¿ coefficients [SEM] ranging from 0.07 [0.04], p < 0.05 to 0.20 [0.04], p < 0.001 in models from early and mid-late pregnancy) and the AA compared to GG genotype was associated with lower pDMG (¿ coefficients [SEM] ranging from -0.11 [0.06], p = 0.055 to -0.23 [0.06], p < 0.001). Conclusion: During pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.
Thematic Areas: Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias ii Engenharias iv Farmacia Food science Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Nutrition & dietetics Nutrition and dietetics Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: michelle.murphy@urv.cat
ISSN: 20726643
Author identifier: 0000-0002-6304-6204
Record's date: 2023-02-22
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/8/10/621
Papper original source: Nutrients. 8 (10):
APA: Colomina J, Cavallé-Busquets P, Fernàndez-Roig S, Solé-Navais P, Fernandez-Ballart J, Ballesteros M, Ueland P, Meyer K, Murphy M (2016). Maternal folate status and the BHMT c.716g>A polymorphism affect the betaine dimethylglycine pathway during pregnancy. Nutrients, 8(10), -. DOI: 10.3390/nu8100621
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/nu8100621
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV