Articles producció científica> Ciències Mèdiques Bàsiques

Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics

  • Identification data

    Identifier: imarina:5130662
    Authors:
    Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I.
    Abstract:
    This study considered the physiological modulation of liver proteins due to the supplementation with fish oils under two dietary backgrounds: standard or high in fat and sucrose (HFHS), and their combination with grape polyphenols. By using a quantitative proteomics approach, we showed that the capacity of the supplements for regulating proteins depended on the diet; namely, 10 different proteins changed into standard diets, while 45 changed into the HFHS diets and only scarcely proteins were found altered in common. However, in both contexts, fish oils were the main regulatory force, although the addition of polyphenols was able to modulate some fish oils' effects. Moreover, we demonstrated the ability of fish oils and their combination with grape polyphenols in improving biochemical parameters and reducing lipogenesis and glycolysis enzymes, enhancing fatty acid beta-oxidation and insulin signaling and ameliorating endoplasmic reticulum stress and protein oxidation when they are included in an unhealthy diet.
  • Others:

    Author, as appears in the article.: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Nogués Llort, Maria Rosa
    Keywords: Wistar kyoto rat Liver protein regulation High-fat, high-sucrose diet Grape polyphenols Fish oils Bioactive compounds liver protein regulation high-fat, high-sucrose diet grape polyphenols fish oils bioactive compounds
    Abstract: This study considered the physiological modulation of liver proteins due to the supplementation with fish oils under two dietary backgrounds: standard or high in fat and sucrose (HFHS), and their combination with grape polyphenols. By using a quantitative proteomics approach, we showed that the capacity of the supplements for regulating proteins depended on the diet; namely, 10 different proteins changed into standard diets, while 45 changed into the HFHS diets and only scarcely proteins were found altered in common. However, in both contexts, fish oils were the main regulatory force, although the addition of polyphenols was able to modulate some fish oils' effects. Moreover, we demonstrated the ability of fish oils and their combination with grape polyphenols in improving biochemical parameters and reducing lipogenesis and glycolysis enzymes, enhancing fatty acid beta-oxidation and insulin signaling and ameliorating endoplasmic reticulum stress and protein oxidation when they are included in an unhealthy diet.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09552863
    Author's mail: mariarosa.nogues@urv.cat
    Author identifier: 0000-0003-4626-5672
    Last page: 97
    Record's date: 2023-02-18
    Journal volume: 41
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0955286316302674?via%3Dihub
    Papper original source: Journal Of Nutritional Biochemistry. 41 84-97
    APA: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I. (2017). Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics. Journal Of Nutritional Biochemistry, 41(), 84-97. DOI: 10.1016/j.jnutbio.2016.12.005
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.jnutbio.2016.12.005
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: 84
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Clinical Biochemistry,Endocrinology, Diabetes and Metabolism,Molecular Biology,Nutrition & Dietetics,Nutrition and Dietetics
    Wistar kyoto rat
    Liver protein regulation
    High-fat, high-sucrose diet
    Grape polyphenols
    Fish oils
    Bioactive compounds
    liver protein regulation
    high-fat, high-sucrose diet
    grape polyphenols
    fish oils
    bioactive compounds
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Molecular biology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
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