Author, as appears in the article.: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep;

Department: Enginyeria Química Enginyeria Informàtica i Matemàtiques Medicina i Cirurgia

URV's Author/s: Fortuny Anguera, Gerard / Herrero Sabartés, Juan / López Besora, Josep Maria / Puigjaner Riba, Maria Dolores

Keywords: Wall shear stress International standard thrombotic treatment Deep venous thrombosis Computational fluid dynamics Biomechanical model international standard thrombotic treatment deep venous thrombosis computational fluid dynamics biomechanical model

Abstract: Deep venous thrombosis (DVT) is a common disease. Large thrombi in venous vessels cause bad blood circulation and pain; and when a blood clot detaches from a vein wall, it causes an embolism whose consequences range from mild to fatal. Walking is recommended to DVT patients as a therapeutical complement. In this study the mechanical effects of walking on a specific patient of DVT were simulated by means of an unprecedented integration of 3 elements: a real geometry, a biomechanical model of body tissues, and a computational fluid dynamics study. A set of computed tomography images of a patient's leg with a thrombus in the popliteal vein was employed to reconstruct a geometry model. Then a biomechanical model was used to compute the new deformed geometry of the vein as a function of the fiber stretch level of the semimembranosus muscle. Finally, a computational fluid dynamics study was performed to compute the blood flow and the wall shear stress (WSS) at the vein and thrombus walls. Calculations showed that either a lengthening or shortening of the semimembranosus muscle led to a decrease of WSS levels up to 10%. Notwithstanding, changes in blood viscosity properties or blood flow rate may easily have a greater impact in WSS.

Thematic Areas: Software Molecular biology Modeling and simulation Medicina ii Medicina i Mathematics, interdisciplinary applications Mathematical & computational biology Interdisciplinar Engineering, biomedical Engenharias iii Engenharias i Educação física Computational theory and mathematics Ciências biológicas ii Ciência da computação Biomedical engineering Applied mathematics

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: josep.m.lopez@urv.cat joan.herrero@urv.cat dolors.puigjaner@urv.cat gerard.fortuny@urv.cat

Author identifier: 0000-0001-7541-8936 0000-0001-8501-1187 0000-0001-5251-2022 0000-0002-2500-7386

Record's date: 2023-05-20

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/cnm.2819

Papper original source: International Journal For Numerical Methods In Biomedical Engineering. 33 (5): e2819-

APA: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep; (2017). Effects of walking in deep venous thrombosis: a new integrated solid and fluid mechanics model. International Journal For Numerical Methods In Biomedical Engineering, 33(5), e2819-. DOI: 10.1002/cnm.2819

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Article's DOI: 10.1002/cnm.2819

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications