Author, as appears in the article.: Lopez, Josep M; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep
Department: Enginyeria Química Enginyeria Informàtica i Matemàtiques Medicina i Cirurgia
URV's Author/s: Fortuny Anguera, Gerard / Herrero Sabartés, Juan / López Besora, Josep Maria / Puigjaner Riba, Maria Dolores
Keywords: Wall shear stress Walking Venous thrombosis Veins Thrombosis Models, biological International standard thrombotic treatment Humans Hemodynamics Deep venous thrombosis Computational fluid dynamics Biomechanical model international standard thrombotic treatment deep venous thrombosis computational fluid dynamics biomechanical model
Abstract: Deep venous thrombosis (DVT) is a common disease. Large thrombi in venous vessels cause bad blood circulation and pain; and when a blood clot detaches from a vein wall, it causes an embolism whose consequences range from mild to fatal. Walking is recommended to DVT patients as a therapeutical complement. In this study the mechanical effects of walking on a specific patient of DVT were simulated by means of an unprecedented integration of 3 elements: a real geometry, a biomechanical model of body tissues, and a computational fluid dynamics study. A set of computed tomography images of a patient's leg with a thrombus in the popliteal vein was employed to reconstruct a geometry model. Then a biomechanical model was used to compute the new deformed geometry of the vein as a function of the fiber stretch level of the semimembranosus muscle. Finally, a computational fluid dynamics study was performed to compute the blood flow and the wall shear stress (WSS) at the vein and thrombus walls. Calculations showed that either a lengthening or shortening of the semimembranosus muscle led to a decrease of WSS levels up to 10%. Notwithstanding, changes in blood viscosity properties or blood flow rate may easily have a greater impact in WSS.
Thematic Areas: Software Molecular biology Modeling and simulation Medicina ii Medicina i Mathematics, interdisciplinary applications Mathematical & computational biology Interdisciplinar Engineering, biomedical Engenharias iii Engenharias i Educação física Computational theory and mathematics Ciências biológicas ii Ciência da computação Biomedical engineering Applied mathematics
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gerard.fortuny@urv.cat dolors.puigjaner@urv.cat joan.herrero@urv.cat josep.m.lopez@urv.cat
Author identifier: 0000-0002-2500-7386 0000-0001-5251-2022 0000-0001-8501-1187 0000-0001-7541-8936
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: International Journal For Numerical Methods In Biomedical Engineering. 33 (5): e2819-
APA: Lopez, Josep M; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep (2017). Effects of walking in deep venous thrombosis: a new integrated solid and fluid mechanics model. International Journal For Numerical Methods In Biomedical Engineering, 33(5), e2819-. DOI: 10.1002/cnm.2819
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications