Articles producció científica> Medicina i Cirurgia

Effects of walking in deep venous thrombosis: a new integrated solid and fluid mechanics model

  • Identification data

    Identifier: imarina:5130734
    Authors:
    Lopez, Josep M.Fortuny, GerardPuigjaner, DolorsHerrero, JoanMarimon, FrancescGarcia-Bennett, Josep
    Abstract:
    Deep venous thrombosis (DVT) is a common disease. Large thrombi in venous vessels cause bad blood circulation and pain; and when a blood clot detaches from a vein wall, it causes an embolism whose consequences range from mild to fatal. Walking is recommended to DVT patients as a therapeutical complement. In this study the mechanical effects of walking on a specific patient of DVT were simulated by means of an unprecedented integration of 3 elements: a real geometry, a biomechanical model of body tissues, and a computational fluid dynamics study. A set of computed tomography images of a patient's leg with a thrombus in the popliteal vein was employed to reconstruct a geometry model. Then a biomechanical model was used to compute the new deformed geometry of the vein as a function of the fiber stretch level of the semimembranosus muscle. Finally, a computational fluid dynamics study was performed to compute the blood flow and the wall shear stress (WSS) at the vein and thrombus walls. Calculations showed that either a lengthening or shortening of the semimembranosus muscle led to a decrease of WSS levels up to 10%. Notwithstanding, changes in blood viscosity properties or blood flow rate may easily have a greater impact in WSS.
  • Others:

    Author, as appears in the article.: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep;
    Department: Enginyeria Química Enginyeria Informàtica i Matemàtiques Medicina i Cirurgia
    URV's Author/s: Fortuny Anguera, Gerard / Herrero Sabartés, Juan / López Besora, Josep Maria / Puigjaner Riba, Maria Dolores
    Keywords: Wall shear stress International standard thrombotic treatment Deep venous thrombosis Computational fluid dynamics Biomechanical model international standard thrombotic treatment deep venous thrombosis computational fluid dynamics biomechanical model
    Abstract: Deep venous thrombosis (DVT) is a common disease. Large thrombi in venous vessels cause bad blood circulation and pain; and when a blood clot detaches from a vein wall, it causes an embolism whose consequences range from mild to fatal. Walking is recommended to DVT patients as a therapeutical complement. In this study the mechanical effects of walking on a specific patient of DVT were simulated by means of an unprecedented integration of 3 elements: a real geometry, a biomechanical model of body tissues, and a computational fluid dynamics study. A set of computed tomography images of a patient's leg with a thrombus in the popliteal vein was employed to reconstruct a geometry model. Then a biomechanical model was used to compute the new deformed geometry of the vein as a function of the fiber stretch level of the semimembranosus muscle. Finally, a computational fluid dynamics study was performed to compute the blood flow and the wall shear stress (WSS) at the vein and thrombus walls. Calculations showed that either a lengthening or shortening of the semimembranosus muscle led to a decrease of WSS levels up to 10%. Notwithstanding, changes in blood viscosity properties or blood flow rate may easily have a greater impact in WSS.
    Thematic Areas: Software Molecular biology Modeling and simulation Medicina ii Medicina i Mathematics, interdisciplinary applications Mathematical & computational biology Interdisciplinar Engineering, biomedical Engenharias iii Engenharias i Educação física Computational theory and mathematics Ciências biológicas ii Ciência da computação Biomedical engineering Applied mathematics
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: gerard.fortuny@urv.cat dolors.puigjaner@urv.cat joan.herrero@urv.cat josep.m.lopez@urv.cat
    Author identifier: 0000-0002-2500-7386 0000-0001-5251-2022 0000-0001-8501-1187 0000-0001-7541-8936
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/cnm.2819
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal For Numerical Methods In Biomedical Engineering. 33 (5): e2819-
    APA: Lopez, Josep M.; Fortuny, Gerard; Puigjaner, Dolors; Herrero, Joan; Marimon, Francesc; Garcia-Bennett, Josep; (2017). Effects of walking in deep venous thrombosis: a new integrated solid and fluid mechanics model. International Journal For Numerical Methods In Biomedical Engineering, 33(5), e2819-. DOI: 10.1002/cnm.2819
    Article's DOI: 10.1002/cnm.2819
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Applied Mathematics,Biomedical Engineering,Computational Theory and Mathematics,Engineering, Biomedical,Mathematical & Computational Biology,Mathematics, Interdisciplinary Applications,Modeling and Simulation,Molecular Biology,Software
    Wall shear stress
    International standard thrombotic treatment
    Deep venous thrombosis
    Computational fluid dynamics
    Biomechanical model
    international standard thrombotic treatment
    deep venous thrombosis
    computational fluid dynamics
    biomechanical model
    Software
    Molecular biology
    Modeling and simulation
    Medicina ii
    Medicina i
    Mathematics, interdisciplinary applications
    Mathematical & computational biology
    Interdisciplinar
    Engineering, biomedical
    Engenharias iii
    Engenharias i
    Educação física
    Computational theory and mathematics
    Ciências biológicas ii
    Ciência da computação
    Biomedical engineering
    Applied mathematics
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