Author, as appears in the article.: Lligadas G, Grama S, Percec V
Department: Química Analítica i Química Orgànica
URV's Author/s: Lligadas Puig, Gerard
Keywords: Monomers Living polymerization Electron transitions
Abstract: Single electron transfer-living radical polymerization (SET-LRP) represents a robust and versatile tool for the synthesis of vinyl polymers with well-defined topology and chain end functionality. The crucial step in SET-LRP is the disproportionation of the Cu(I)X generated by activation with Cu(0) wire, powder, or nascent Cu(0) generated in situ into nascent, extremely reactive Cu(0) atoms and nanoparticles and Cu(II)X2. Nascent Cu(0) activates the initiator and dormant chains via a homogeneous or heterogeneous outer-sphere single-electron transfer mechanism (SET-LRP). SET-LRP provides an ultrafast polymerization of a plethora of monomers (e.g., (meth)-acrylates, (meth)-acrylamides, styrene, and vinyl chloride) including hydrophobic and water insoluble to hydrophilic and water soluble. Some advantageous features of SET-LRP are (i) the use of Cu(0) wire or powder as readily available catalysts under mild reaction conditions, (ii) their excellent control over molecular weight evolution and distribution as well as polymer chain ends, (iii) their high functional group tolerance allowing the polymerization of commercial-grade monomers, and (iv) the limited purification required for the resulting polymers. In this Perspective, we highlight the recent advancements of SET-LRP in the synthesis of biomacromolecules and of their conjugates.
Thematic Areas: Química Polymers and plastics Polymer science Medicina ii Materials chemistry Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, organic Biotecnología Biomaterials Bioengineering Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gerard.lligadas@urv.cat
Author identifier: 0000-0002-8519-1840
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/acs.biomac.7b00197
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Biomacromolecules. 18 (4): 1039-1063
APA: Lligadas G, Grama S, Percec V (2017). Recent Developments in the Synthesis of Biomacromolecules and their Conjugates by Single Electron Transfer Living Radical Polymerization. Biomacromolecules, 18(4), 1039-1063. DOI: 10.1021/acs.biomac.7b00197
Article's DOI: 10.1021/acs.biomac.7b00197
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV