Author, as appears in the article.: Jackson, Colette E.; Castagno, Davide; Maggioni, Aldo P.; Kober, Lars; Squire, Iain B.; Swedberg, Karl; Andersson, Bert; Richards, A. Mark; Bayes-Genis, Antoni; Tribouilloy, Christophe; Dobson, Joanna; Ariti, Cono A.; Poppe, Katrina K.; Earle, Nikki; Whalley, Gillian; Pocock, Stuart J.; Doughty, Robert N.; McMurray, John J. V.;Meta-Anal Global Grp Chronic He
Department: Medicina i Cirurgia
URV's Author/s: Bardají Ruiz, Alfredo
Keywords: Wave velocity Survival Risk Reduced ejection fraction Pulse pressure Preserved ejection fraction Onset atrial-fibrillation Mortality Independent predictor Heart failure Differential impact Blood-pressure Association Acute myocardial-infarction pulse pressure preserved ejection fraction mortality heart failure
Abstract: Low pulse pressure is a marker of adverse outcome in patients with heart failure (HF) and reduced ejection fraction (HF-REF) but the prognostic value of pulse pressure in patients with HF and preserved ejection fraction (HF-PEF) is unknown. We examined the prognostic value of pulse pressure in patients with HF-PEF [ejection fraction (EF) ? 50%] and HF-REF.Data from 22 HF studies were examined. Preserved left ventricular ejection fraction (LVEF) was defined as LVEF ? 50%. All-cause mortality at 3 years was evaluated in 27 046 patients: 22 038 with HF-REF (4980 deaths) and 5008 with HF-PEF (828 deaths). Pulse pressure was analysed in quintiles in a multivariable model adjusted for the previously reported Meta-Analysis Global Group in Chronic Heart Failure prognostic variables. Heart failure and reduced ejection fraction patients in the lowest pulse pressure quintile had the highest crude and adjusted mortality risk (adjusted hazard ratio 1.68, 95% confidence interval 1.53-1.84) compared with all other pulse pressure groups. For patients with HF-PEF, higher pulse pressure was associated with the highest crude mortality, a gradient that was eliminated after adjustment for other prognostic variables.Lower pulse pressure (especially <53 mmHg) was an independent predictor of mortality in patients with HF-REF, particularly in those with an LVEF < 30% and systolic blood pressure <140 mmHg. Overall, this relationship between pulse pressure and outcome was not consistently observed among patients with HF-PEF.Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
Thematic Areas: Saúde coletiva Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Direito Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: alfredo.bardaji@urv.cat
Author identifier: 0000-0003-1900-6974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Heart Journal. 36 (18): 1106-1114
APA: Jackson, Colette E.; Castagno, Davide; Maggioni, Aldo P.; Kober, Lars; Squire, Iain B.; Swedberg, Karl; Andersson, Bert; Richards, A. Mark; Bayes-Geni (2015). Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: results from the MAGGIC individual patient meta-analysis. European Heart Journal, 36(18), 1106-1114. DOI: 10.1093/eurheartj/ehu490
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV