Author, as appears in the article.: Navarro, Silvia V; Alvarez, Roberto; Colomina, M Teresa; Sanchez-Santed, Fernando; Flores, Pilar; Moreno, Margarita
Department: Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa
Keywords: Schizophrenia Schedule-induced polydipsia Reversal learning Rats, wistar Rats Myelination Latent inhibition Inhibition, psychological Endophenotypes Drinking behavior Disease models, animal Corpus striatum Corpus callosum Compulsivity Compulsive behavior Biomarkers Behavior, animal Animals Amygdala schedule-induced polydipsia reversal learning myelination latent inhibition compulsivity
Abstract: Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%-20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.
Thematic Areas: Saúde coletiva Psychology Psychiatry and mental health Psychiatry Psicología Medicine (all) Medicina ii Medicina i Materiais General medicine Farmacia Clinical neurology Ciencias sociales Ciências biológicas ii
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariateresa.colomina@urv.cat
Author identifier: 0000-0002-5619-4874
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Schizophrenia Bulletin. 43 (4): 778-787
APA: Navarro, Silvia V; Alvarez, Roberto; Colomina, M Teresa; Sanchez-Santed, Fernando; Flores, Pilar; Moreno, Margarita (2017). Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders. Schizophrenia Bulletin, 43(4), 778-787. DOI: 10.1093/schbul/sbw141
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV