Author, as appears in the article.: Auladell C; de Lemos L; Verdaguer E; Ettcheto M; Busquets O; Lazarowski A; Beas-Zarate C; Olloquequi J; Folch J; Camins A

Department: Bioquímica i Biotecnologia

URV's Author/s: Folch Lopez, Jaume

Keywords: Review Neuroprotection Kainic acid Hippocampus Energy metabolism C-jun n-terminal kinase signaling pathway Apoptosis Amyloid beta protein

Abstract: Chemoconvulsants that induce status epilepticus in rodents have been widely used over the past decades due to their capacity to reproduce with high similarity neuropathological and electroencephalographic features observed in patients with temporal lobe epilepsy (TLE). Kainic acid is one of the most used chemoconvulsants in experimental models. KA administration mainly induces neuronal loss in the hippocampus. We focused the present review inthe c-Jun N-terminal kinase-signaling pathway (JNK), since it has been shown to play a key role in the process of neuronal death following KA activation. Among the three isoforms of JNK (JNK1, JNK2, JNK3), JNK3 is widely localized in the majority of areas of the hippocampus, whereas JNK1 levels are located exclusively in the CA3 and CA4 areas and in dentate gyrus. Disruption of the gene encoding JNK3 in mice renders neuroprotection to KA, since these animals showed a reduction in seizure activity and a diminution in hippocampal neuronal apoptosis. In light of this, JNK3 could be a promising subcellular target for future therapeutic interventions in epilepsy.

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 10934715

Author's mail: jaume.folch@urv.cat

Author identifier: 0000-0002-5051-8858

Record's date: 2023-03-05

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://europepmc.org/article/med/27814647

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Front Biosci (Landmark Ed). 22 (5): 795-814

APA: Auladell C; de Lemos L; Verdaguer E; Ettcheto M; Busquets O; Lazarowski A; Beas-Zarate C; Olloquequi J; Folch J; Camins A (2017). Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration. Front Biosci (Landmark Ed), 22(5), 795-814. DOI: 10.2741/4517

Article's DOI: 10.2741/4517

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications