Author, as appears in the article.: Busquets, Oriol; Ettcheto, Miren; Pallas, Merce; Beas-Zarate, Carlos; Verdaguer, Ester; Auladell, Carme; Folch, Jaume; Camins, Antoni
Department: Bioquímica i Biotecnologia
URV's Author/s: Folch Lopez, Jaume
Keywords: Β-amyloid; Up-regulation; Type 2 diabetes mellitus; T2dm, type 2 diabetes mellitus; T2dm; Ptp1β; Ptp1?; Ptp1 beta, protein tyrosine phosphatase 1 beta; Protein tyrosine phosphatase 1β; Protein tyrosine phosphatase 1?; Obesity; Mitogen-activated protein kinase; Mice; Metabolic syndrome; Mechanisms; Mapk, mitogen-activated protein kinase; Mapk; Load, late-onset alzheimer's disease; Load; Late-onset alzheimer’s disease; Late-onset alzheimer's disease; Jnk; Insulin-like growth factor-1; Inflammation; Igf-1, insulin-like growth factor-1; Igf-1; Humans; High-fat diet; High calorie diet; Hfd, high-fat diet; Hfd; Hcd, high calorie diet; Hcd; Expression; Energy metabolism; Disease models, animal; Dio, diet-induced obesity; Dio; Dietary fats; Diet-induced obesity; Csf, cerebrospinal fluid; Csf; Cerebrospinal fluid; Brain blood barrier; Brain; Beta-site app-cleaving enzyme 1; Bbb, brain blood barrier; Bbb; Bace1, beta-site app-cleaving enzyme 1; Bace1; Aβ; Autophagy; Autonomic nervous system; Ans. autonomic nervous system; Ans; Animals; Amyloid beta-peptides; Amyloid beta protein; Ampk; Ampik amp-activated protein kinase; Amp-activated protein kinase; Alzheimer’s disease; Alzheimer's disease; Alzheimer disease; Aging; Ad, alzheimer's disease; Ad; A?; A beta, beta-amyloid; ?-amyloid; type 2 diabetes mellitus; t2dm; ptp1?; protein tyrosine phosphatase 1?; mitogen-activated protein kinase; mapk; load; late-onset alzheimer’s disease; insulin-like growth factor-1; igf-1; high-fat diet; high calorie diet; hfd; hcd; dio; diet-induced obesity; csf; cerebrospinal fluid; brain blood barrier; beta-site app-cleaving enzyme 1; bbb; bace1; autonomic nervous system; ans; ampk; amp-activated protein kinase; alzheimer’s disease; ad; a?
Abstract: AIMS: The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most common form of dementia. This non-familiar form could be a consequence of metabolic syndrome, characterized by obesity and the development of a brain-specific insulin resistance known as type III diabetes. This work demonstrates the development of a significant AD-like neuropathology due to these metabolic alterations. METHODS: C57BL/6J mice strain were divided into two groups, one fed with a diet rich in palmitic acid (high-fat diet, HFD) since their weaning until 16 months of age, and another group used as a control with a regular diet. The analyses were carried out in the dentate gyrus area of the hippocampus using a Thioflavin-S stain and immunofluorescence assays. RESULTS: The most significant finding of the present research was that HFD induced the deposition of the βA peptide. Moreover, the diet also caused alterations in different cell processes, such as increased inflammatory reactions that lead to a decrease in the neuronal precursor cells. In addition, the results show that there were also dysregulations in normal autophagy and apoptosis, mechanisms related to βA formation. CONCLUSIONS: The present findings confirm that HFD favors the formation of βA depositions in the brain, a key feature of AD, supporting the metabolic hypothesis of sporadic AD.
Thematic Areas: Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Geriatrics & gerontology; Educação física; Developmental biology; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Cell biology; Biotecnología; Biochemistry & molecular biology; Aging
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00476374
Author's mail: jaume.folch@urv.cat
Record's date: 2024-10-19
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0047637416300859?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Mechanisms Of Ageing And Development. 162 38-45
APA: Busquets, Oriol; Ettcheto, Miren; Pallas, Merce; Beas-Zarate, Carlos; Verdaguer, Ester; Auladell, Carme; Folch, Jaume; Camins, Antoni (2017). Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease. Mechanisms Of Ageing And Development, 162(), 38-45. DOI: 10.1016/j.mad.2016.11.002
Article's DOI: 10.1016/j.mad.2016.11.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV