Articles producció científica> Ciències Mèdiques Bàsiques

TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.

  • Identification data

    Identifier: imarina:5131236
    Authors:
    Celia SequeraAna Vázquez CarballoMaría ArechederraSonia Fernández VeledoAlmudena Porras.
    Abstract:
    TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38? MAPK promotes migration and invasion in several cancer cells types and in mouse embryonic fibroblasts (MEFs). However, it remains unknown if TWEAK could promote migration in fibroblasts and whether p38? MAPK might play a role. Our results reveal that TWEAK activates ERKs, Akt, and p38?/? MAPKs and reduces secreted Fibulin 3 in MEFs. TWEAK also increases migration and invasion in wt and p38? deficient MEFs, which indicates that p38? MAPK is not required to mediate these effects. In contrast, ERKs inhibition significantly decreases TWEAK-induced migration and Fibulin 3 knock-down mimics TWEAK effect. These results indicate that both ERKs activation and Fibulin 3 down-regulation would contribute to mediate TWEAK pro-migratory effect. In fact, the additional regulation of ERKs and/or p38? as a consequence of Fibulin 3 decrease might be also involved in the pro-migratory effect of TWEAK in MEFs. In conclusion, our studies uncover novel mechanisms by which TWEAK would favor tissue repair by promoting fibroblasts migration.© 2017 Wiley Periodicals, Inc.
  • Others:

    Author, as appears in the article.: Celia Sequera; Ana Vázquez Carballo; María Arechederra; Sonia Fernández Veledo; Almudena Porras.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Fernandez Veledo, Sonia
    Keywords: Weak inducer Tweak Tnf-alpha Superfamily member Nf-kappa-b Multifunctional cytokine Migration Kinase Glioma-cell invasion Fibulin 3 Fibrosis Expression Erks Apoptosis tweak tweak fibulin 3 erks
    Abstract: TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38? MAPK promotes migration and invasion in several cancer cells types and in mouse embryonic fibroblasts (MEFs). However, it remains unknown if TWEAK could promote migration in fibroblasts and whether p38? MAPK might play a role. Our results reveal that TWEAK activates ERKs, Akt, and p38?/? MAPKs and reduces secreted Fibulin 3 in MEFs. TWEAK also increases migration and invasion in wt and p38? deficient MEFs, which indicates that p38? MAPK is not required to mediate these effects. In contrast, ERKs inhibition significantly decreases TWEAK-induced migration and Fibulin 3 knock-down mimics TWEAK effect. These results indicate that both ERKs activation and Fibulin 3 down-regulation would contribute to mediate TWEAK pro-migratory effect. In fact, the additional regulation of ERKs and/or p38? as a consequence of Fibulin 3 decrease might be also involved in the pro-migratory effect of TWEAK in MEFs. In conclusion, our studies uncover novel mechanisms by which TWEAK would favor tissue repair by promoting fibroblasts migration.© 2017 Wiley Periodicals, Inc.
    Thematic Areas: Química Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cell biology Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00219541
    Author's mail: sonia.fernandez@urv.cat
    Author identifier: 0000-0003-2906-3788
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.25942
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Cellular Physiology. 233 (2): 968-978
    APA: Celia Sequera; Ana Vázquez Carballo; María Arechederra; Sonia Fernández Veledo; Almudena Porras. (2018). TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.. Journal Of Cellular Physiology, 233(2), 968-978. DOI: 10.1002/jcp.25942
    Article's DOI: 10.1002/jcp.25942
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Cell Biology,Clinical Biochemistry,Physiology
    Weak inducer
    Tweak
    Tnf-alpha
    Superfamily member
    Nf-kappa-b
    Multifunctional cytokine
    Migration
    Kinase
    Glioma-cell invasion
    Fibulin 3
    Fibrosis
    Expression
    Erks
    Apoptosis tweak
    tweak
    fibulin 3
    erks
    Química
    Physiology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Ciência da computação
    Cell biology
    Biotecnología
    Biodiversidade
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