Project code: CTQ2013-46404-R
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Lab On A Chip. 17 (14): 2500-2507
APA: Cánovas R; Parrilla M.; Blondeau P.; Andrade F.J. (2017). A novel wireless paper-based potentiometric platform for monitoring glucose in blood. Lab On A Chip, 17(14), 2500-2507. DOI: 10.1039/c7lc00339k
Acronym: 'Plataformas electroquímicas descentralizadas'
Publication Type: Journal Publications
Author, as appears in the article.: Cánovas R; Parrilla M.; Blondeau P.; Andrade F.J.
Department: Química Analítica i Química Orgànica
Acronym 2: HOMESENS
URV's Author/s: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
Abstract: A novel low-cost, compact and sensitive paper-based platform for the accurate monitoring of glucose in biological fluids is presented. Paper-based working and reference electrodes are combined to build a whole potentiometric cell, which also fits a sampling module for simple and fast determination of glucose in a single drop of blood. The working electrode is built using a platinized filter paper coated with a Nafion membrane that entraps the enzyme glucose oxidase; the reference electrode is made by casting a polyvinylbutyral-based membrane onto a conductive paper. The system works by detecting the hydrogen peroxide generated as a result of the enzymatic reaction. Selectivity is achieved due to the permselective behaviour of Nafion, while a significant enhancement of the sensitivity is reached by exploiting the Donnan-coupled formal potential. Under optimum conditions, a sensitivity of −95.9 ± 4.8 mV per decade in the 0.3-3 mM range is obtained. Validation of the measurements has been performed against standard methods in human serum and blood. Final integration with a wireless reader allows for truly in situ measurements with a less than 2 minute procedure including a two-point calibration, washing and measurement. This low-cost analytical device opens up new prospects for rapid diagnostic results in nonlaboratory settings.
Program founding action 2: Proyecto de I+D
Thematic Areas: Química Nanoscience and nanotechnology Nanoscience & nanotechnology Materiais Interdisciplinar Instruments & instrumentation General medicine General chemistry Farmacia Engenharias iv Engenharias ii Chemistry, multidisciplinary Chemistry, analytical Chemistry (miscellaneous) Chemistry (all) Biotecnología Biomedical engineering Bioengineering Biochemistry Biochemical research methods Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14730189
Author's mail: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
Author identifier: 0000-0003-1331-5055 0000-0003-1199-2837
Project code 2: CTQ2016-77128-R
Founding program 2: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc00339k#!divAbstract
Funding program: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
Article's DOI: 10.1039/c7lc00339k
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Funding program action: Proyecto de investigación