Articles producció científicaQuímica Física i Inorgànica

Metal‐Free Synthesis of N‐Aryl Amides using Organocatalytic Ring‐Opening Aminolysis of Lactones

  • Identification data

    Identifier:  imarina:5131443
    Handle: https://hdl.handle.net/20.500.11797/imarina5131443
    Authors:  Guo, WS; Gómez, JE; Martínez-Rodríguez, L; Bandeira, NAG; Bo, C; Kleij, AW
    Abstract:
    Catalytic ring-opening of bio-sourced non-strained lactones with aromatic amines can offer a straightforward, 100% atom-economical, and sustainable pathway towards relevant N-aryl amide scaffolds. Herein, the first general, metal-free, and highly efficient N-aryl amide formation is reported from poorly reactive aromatic amines and non-strained lactones under mild operating conditions using an organic bicyclic guanidine catalyst. This protocol has high application potential as exemplified by the formal syntheses of drug-relevant molecules.

  • Others:

    Link to the original source: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.201700415
    APA: Guo, WS; Gómez, JE; Martínez-Rodríguez, L; Bandeira, NAG; Bo, C; Kleij, AW (2017). Metal‐Free Synthesis of N‐Aryl Amides using Organocatalytic Ring‐Opening Aminolysis of Lactones. Chemsuschem, 10(9), 1969-1975. DOI: 10.1002/cssc.201700415
    Paper original source: Chemsuschem. 10 (9): 1969-1975
    Article's DOI: 10.1002/cssc.201700415
    Journal publication year: 2017-05-09
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2026-05-09
    URV's Author/s: Bo Jané, Carles
    Department: Química Física i Inorgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Guo, WS; Gómez, JE; Martínez-Rodríguez, L; Bandeira, NAG; Bo, C; Kleij, AW
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Materials science (miscellaneous), Materials science (all), Green & sustainable science & technology, General materials science, General energy, General chemical engineering, Environmental chemistry, Engenharias ii, Energy (miscellaneous), Energy (all), Chemistry, multidisciplinary, Chemical engineering (miscellaneous), Chemical engineering (all), Biotecnología, Astronomia / física
    Author's mail: carles.bo@urv.cat, carles.bo@urv.cat

  • Keywords:

    Ring-opening aminolysis
    Organocatalysis
    N-aryl amides
    Lactones
    Aromatic amines
    Chemical Engineering (Miscellaneous)
    Chemistry
    Multidisciplinary
    Energy (Miscellaneous)
    Environmental Chemistry
    Green & Sustainable Science & Technology
    Materials Science (Miscellaneous)
    Materials science (all)
    General materials science
    General energy
    General chemical engineering
    Engenharias ii
    Energy (all)
    Chemical engineering (all)
    Biotecnología
    Astronomia / física

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