Author, as appears in the article.: Camps, J; Iftimie, S; García-Heredia, A; Castro, A; Joven, J
Department: Medicina i Cirurgia
URV's Author/s: Camps Andreu, Jorge / Castro Salomó, Antoni / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge
Keywords: Serum paraoxonase Risk-factor Quorum-sensing signal Quorum sensing Pseudomonas-aeruginosa Paraoxonases Oxidative stress Lactonases Inflammation Infection Hiv-infection High-density-lipoprotein Hepatitis-b-virus Helicobacter-pylori Gene-expression paraoxonases oxidative stress lactonases inflammation infection
Abstract: The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity. These alterations have clinical consequences for the infected patient, including an increased risk for cardiovascular diseases, and an impaired protection against the formation of antibiotic-resistant bacterial biofilms. Several studies have investigated the value of serum PON1 measurement as a biomarker of the infection process. Low serum PON1 activities are associated with poor survival in patients with severe sepsis. In addition, preliminary studies suggest that serum PON1 concentration and/or enzyme activity may be useful as markers of acute concomitant infection in patients with an indwelling central venous catheter. Investigating the associations between paraoxonases and infectious diseases is a recent, and productive, line of research.
Thematic Areas: Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ensino Educação física Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00099120
Author's mail: simonamihaela.iftime@urv.cat jorge.camps@urv.cat jorge.joven@urv.cat antoni.castro@urv.cat
Author identifier: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-5441-6333
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0009912017301005
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Biochemistry. 50 (13-14): 804-811
APA: Camps, J; Iftimie, S; García-Heredia, A; Castro, A; Joven, J (2017). Paraoxonases and infectious diseases. Clinical Biochemistry, 50(13-14), 804-811. DOI: 10.1016/j.clinbiochem.2017.04.016
Article's DOI: 10.1016/j.clinbiochem.2017.04.016
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications