Articles producció científica> Medicina i Cirurgia

Paraoxonases and infectious diseases

  • Identification data

    Identifier: imarina:5131706
    Authors:
    Camps, JIftimie, SGarcía-Heredia, ACastro, AJoven, J
    Abstract:
    The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity. These alterations have clinical consequences for the infected patient, including an increased risk for cardiovascular diseases, and an impaired protection against the formation of antibiotic-resistant bacterial biofilms. Several studies have investigated the value of serum PON1 measurement as a biomarker of the infection process. Low serum PON1 activities are associated with poor survival in patients with severe sepsis. In addition, preliminary studies suggest that serum PON1 concentration and/or enzyme activity may be useful as markers of acute concomitant infection in patients with an indwelling central venous catheter. Investigating the associations between paraoxonases and infectious diseases is a recent, and productive, line of research.
  • Others:

    Author, as appears in the article.: Camps, J; Iftimie, S; García-Heredia, A; Castro, A; Joven, J
    Department: Medicina i Cirurgia
    URV's Author/s: Camps Andreu, Jorge / Castro Salomó, Antoni / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge
    Keywords: Serum paraoxonase Risk-factor Quorum-sensing signal Quorum sensing Pseudomonas-aeruginosa Paraoxonases Oxidative stress Lactonases Inflammation Infection Hiv-infection High-density-lipoprotein Hepatitis-b-virus Helicobacter-pylori Gene-expression paraoxonases oxidative stress lactonases inflammation infection
    Abstract: The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity. These alterations have clinical consequences for the infected patient, including an increased risk for cardiovascular diseases, and an impaired protection against the formation of antibiotic-resistant bacterial biofilms. Several studies have investigated the value of serum PON1 measurement as a biomarker of the infection process. Low serum PON1 activities are associated with poor survival in patients with severe sepsis. In addition, preliminary studies suggest that serum PON1 concentration and/or enzyme activity may be useful as markers of acute concomitant infection in patients with an indwelling central venous catheter. Investigating the associations between paraoxonases and infectious diseases is a recent, and productive, line of research.
    Thematic Areas: Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ensino Educação física Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00099120
    Author's mail: simonamihaela.iftime@urv.cat jorge.camps@urv.cat jorge.joven@urv.cat antoni.castro@urv.cat
    Author identifier: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-5441-6333
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0009912017301005
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Biochemistry. 50 (13-14): 804-811
    APA: Camps, J; Iftimie, S; García-Heredia, A; Castro, A; Joven, J (2017). Paraoxonases and infectious diseases. Clinical Biochemistry, 50(13-14), 804-811. DOI: 10.1016/j.clinbiochem.2017.04.016
    Article's DOI: 10.1016/j.clinbiochem.2017.04.016
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Clinical Biochemistry,Medical Laboratory Technology,Medicine (Miscellaneous)
    Serum paraoxonase
    Risk-factor
    Quorum-sensing signal
    Quorum sensing
    Pseudomonas-aeruginosa
    Paraoxonases
    Oxidative stress
    Lactonases
    Inflammation
    Infection
    Hiv-infection
    High-density-lipoprotein
    Hepatitis-b-virus
    Helicobacter-pylori
    Gene-expression
    paraoxonases
    oxidative stress
    lactonases
    inflammation
    infection
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Medical laboratory technology
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Educação física
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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