Author, as appears in the article.: Lligadas G, Enayati M, Grama S, Smail R, Sherman SE, Percec V

Department: Química Analítica i Química Orgànica

e-ISSN: 1526-4602

URV's Author/s: Lligadas Puig, Gerard

Keywords: Vinyl-chloride Single-electron-transfer Methyl acrylate Living radical polymerization Free radical reactions Dramatic acceleration Divergent synthesis Dendritic macromolecules Cu(0) wire Conventional monomers Biology Amide functional initiators

Abstract: To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers in biological environments. Here, we report that stable 2-bromopropionyl peptoid-type initiators such as 1,4-bis(2-bromopropionyl)piperazine and 4-(2-bromopropionyl)morpholine are an alternative that meets the standards reached by the well-known secondary and tertiary ¿-haloester-type initiators in terms of excellent control over molecular weight evolution and distribution as well as polymer chain ends. SET-LRP methodologies in organic, aqueous, and biphasic organic-aqueous media were evaluated for this purpose.

Thematic Areas: Química Polymers and plastics Polymer science Medicina ii Materials chemistry Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, organic Biotecnología Biomaterials Bioengineering Biochemistry & molecular biology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1525-7797

Author's mail: gerard.lligadas@urv.cat

Author identifier: 0000-0002-8519-1840

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/acs.biomac.7b00722

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Biomacromolecules. 18 (8): 2610-2622

APA: Lligadas G, Enayati M, Grama S, Smail R, Sherman SE, Percec V (2017). Ultrafast SET-LRP with Peptoid Cytostatic Drugs as Monofunctional and Bifunctional Initiators. Biomacromolecules, 18(8), 2610-2622. DOI: 10.1021/acs.biomac.7b00722

Article's DOI: 10.1021/acs.biomac.7b00722

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications