Ultrafast SET-LRP with Peptoid Cytostatic Drugs as Monofunctional and Bifunctional Initiators

Identifier:  imarina:5131869

Handle: https://hdl.handle.net/20.500.11797/imarina5131869

Authors:  Lligadas, G; Enayati, M; Grama, S; Smail, R; Sherman, SE; Percec, V

Abstract:
To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers in biological environments. Here, we report that stable 2-bromopropionyl peptoid-type initiators such as 1,4-bis(2-bromopropionyl)piperazine and 4-(2-bromopropionyl)morpholine are an alternative that meets the standards reached by the well-known secondary and tertiary ¿-haloester-type initiators in terms of excellent control over molecular weight evolution and distribution as well as polymer chain ends. SET-LRP methodologies in organic, aqueous, and biphasic organic-aqueous media were evaluated for this purpose.