Articles producció científica> Bioquímica i Biotecnologia

Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats

  • Identification data

    Identifier: imarina:5131968
    Authors:
    Casanova-Marti, AngelaSerrano, JoanPortune, Kevin JSanz, YolandaTeresa Blay, MTerra, XimenaArdevol, AnnaPinent, Montserrat
    Abstract:
    Grape seed proanthocyanidin extract (GSPE) modulates several parameters involved in metabolic syndrome. GSPE is a mixture of compounds, some which are rapidly absorbed, while others remain in the lumen where they might have effects that are translated to the whole organism. Our aim was to decipher if the 8-day treatment of GSPE, previously shown to reduce food intake, induces changes in the microbiota and enterohormone secretion. The ratio of Firmicutes?:?Bacteroidetes was lower in the microbiota of GSPE-treated rats compared to controls, and differences in several taxonomic families and genera were observed. Such modulation led to a reduction in cecal butyrate content. GSPE also increased plasma glucagon-like-peptide-1 (GLP-1). Gallic acid did not induce major changes in the microbiota profile nor in GLP-1 secretion. Correlations between several microbiota taxa and plasma triacylglycerol, adiposity, and enterohormones were observed. Modulation of microbiota may be one of the mechanism by which GSPE impacts metabolic health.
  • Others:

    Author, as appears in the article.: Casanova-Marti, Angela; Serrano, Joan; Portune, Kevin J; Sanz, Yolanda; Teresa Blay, M; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
    Keywords: Rats, wistar Rats Proanthocyanidins Metabolic syndrome Humans Grape seed proanthocyanidins Grape seed extract Glucagon-like peptide 1 Gastrointestinal microbiome Gallic acid Female Butyrates Bacteria Animals Adiposity
    Abstract: Grape seed proanthocyanidin extract (GSPE) modulates several parameters involved in metabolic syndrome. GSPE is a mixture of compounds, some which are rapidly absorbed, while others remain in the lumen where they might have effects that are translated to the whole organism. Our aim was to decipher if the 8-day treatment of GSPE, previously shown to reduce food intake, induces changes in the microbiota and enterohormone secretion. The ratio of Firmicutes?:?Bacteroidetes was lower in the microbiota of GSPE-treated rats compared to controls, and differences in several taxonomic families and genera were observed. Such modulation led to a reduction in cecal butyrate content. GSPE also increased plasma glucagon-like-peptide-1 (GLP-1). Gallic acid did not induce major changes in the microbiota profile nor in GLP-1 secretion. Correlations between several microbiota taxa and plasma triacylglycerol, adiposity, and enterohormones were observed. Modulation of microbiota may be one of the mechanism by which GSPE impacts metabolic health.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 29938270
    Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2018/FO/C7FO02028G#!divAbstract
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food & Function. 9 (3): 1672-1682
    APA: Casanova-Marti, Angela; Serrano, Joan; Portune, Kevin J; Sanz, Yolanda; Teresa Blay, M; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat (2018). Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats. Food & Function, 9(3), 1672-1682. DOI: 10.1039/c7fo02028g
    Article's DOI: 10.1039/c7fo02028g
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Food Science,Food Science & Technology,Medicine (Miscellaneous)
    Rats, wistar
    Rats
    Proanthocyanidins
    Metabolic syndrome
    Humans
    Grape seed proanthocyanidins
    Grape seed extract
    Glucagon-like peptide 1
    Gastrointestinal microbiome
    Gallic acid
    Female
    Butyrates
    Bacteria
    Animals
    Adiposity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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