Articles producció científicaMedicina i Cirurgia

Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy

  • Identification data

    Identifier:  imarina:5132033
    Handle: https://hdl.handle.net/20.500.11797/imarina5132033
    Authors:  Rodriguez-Gallego, Esther; Gomez, Josep; Domingo, Pere; Ferrando-Martinez, Sara; Peraire, Joaquim; Vilades, Consuelo; Veloso, Sergi; Lopez-Dupla, Miguel; Beltran-Debon, Raul; Alba, Veronica; Vargas, Montserrat; Castellano, Alfonso J; Leal, Manuel; Maria Pacheco, Yolanda; Ruiz-Mateos, Ezequiel; Gutierrez, Felix; Vidal, Francesc; Rull, Anna
    Abstract:
    © 2018 The Authors Background and aims: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. Methods: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months. Univariate and multivariate analyses were performed to evaluate the predictive power of NMR spectroscopy. Results: VLDL-metabolism (including VLDL lipid concentrations, sizes, and particle numbers), total triglycerides and lactate levels resulted in good classifiers of dyslipidemia (AUC 0.903). Total particles/HDL-P ratio was significantly higher in ART-associated dyslipidemia compared to ART-normolipidemia (p = 0.001). Large VLDL-Ps were positively associated with both LDL-triglycerides (ρ 0.682, p < 0.001) and lactate concentrations (ρ 0.416, p < 0.001), the last one a marker of mitochondrial low oxidative capacity. Conclusions: Our data suggest that circulating metabolites have better predictive values for HIV/ART-related dyslipidemia onset than do the biochemical markers associated with conventional lipid measurements. NMR identifies changes in VLDL-P, lactate and LDL-TG as potential clinical markers of baseline HIV-dyslipidemia predisposition. Differences in circulating metabolomics, especially differences in particle size, are indicators of important derangements of mitochondrial function

  • Others:

    Author, as appears in the article.: Rodriguez-Gallego, Esther; Gomez, Josep; Domingo, Pere; Ferrando-Martinez, Sara; Peraire, Joaquim; Vilades, Consuelo; Veloso, Sergi; Lopez-Dupla, Miguel; Beltran-Debon, Raul; Alba, Veronica; Vargas, Montserrat; Castellano, Alfonso J; Leal, Manuel; Maria Pacheco, Yolanda; Ruiz-Mateos, Ezequiel; Gutierrez, Felix; Vidal, Francesc; Rull, Anna
    Department: Bioquímica i Biotecnologia; Medicina i Cirurgia
    URV's Author/s: Beltrán Debón, Raúl Alejandro / Gómez Alvarez, Josep / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
    Keywords: Triglycerides; Predictive value of tests; Nmr; Middle aged; Metabolomics; Metabolome; Male; Lipoproteins; Lipids; Humans; Hiv infections; Hiv; Female; Dyslipidemias; Dyslipidemia; Cholesterol; Art therapy; Anti-retroviral agents; Adult; metabolomics; lipoproteins; lipids; hiv; dyslipidemia; art therapy
    Abstract: © 2018 The Authors Background and aims: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. Methods: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months. Univariate and multivariate analyses were performed to evaluate the predictive power of NMR spectroscopy. Results: VLDL-metabolism (including VLDL lipid concentrations, sizes, and particle numbers), total triglycerides and lactate levels resulted in good classifiers of dyslipidemia (AUC 0.903). Total particles/HDL-P ratio was significantly higher in ART-associated dyslipidemia compared to ART-normolipidemia (p = 0.001). Large VLDL-Ps were positively associated with both LDL-triglycerides (ρ 0.682, p < 0.001) and lactate concentrations (ρ 0.416, p < 0.001), the last one a marker of mitochondrial low oxidative capacity. Conclusions: Our data suggest that circulating metabolites have better predictive values for HIV/ART-related dyslipidemia onset than do the biochemical markers associated with conventional lipid measurements. NMR identifies changes in VLDL-P, lactate and LDL-TG as potential clinical markers of baseline HIV-dyslipidemia predisposition. Differences in circulating metabolomics, especially differences in particle size, are indicators of important derangements of mitochondrial function that are linked to ART-related dyslipidemia.
    Thematic Areas: Saúde coletiva; Psicología; Peripheral vascular disease; Odontología; Nutrição; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciência de alimentos; Ciência da computação; Cardiology and cardiovascular medicine; Cardiac & cardiovascular systems; Biotecnología; Antropologia / arqueologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00219150
    Author's mail: josep.gomez@urv.cat; joaquim.peraire@urv.cat; consuelo.vilades@urv.cat; francesc.vidal@urv.cat; raul.beltran@urv.cat; jesusmiguel.lopez@urv.cat
    Record's date: 2025-02-18
    Paper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.atherosclerosis-journal.com/article/S0021-9150(18)30182-5/fulltext
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Atherosclerosis. 273 28-36
    APA: Rodriguez-Gallego, Esther; Gomez, Josep; Domingo, Pere; Ferrando-Martinez, Sara; Peraire, Joaquim; Vilades, Consuelo; Veloso, Sergi; Lopez-Dupla, Migu (2018). Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy. Atherosclerosis, 273(), 28-36. DOI: 10.1016/j.atherosclerosis.2018.04.008
    Article's DOI: 10.1016/j.atherosclerosis.2018.04.008
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications

  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease
    Triglycerides
    Predictive value of tests
    Nmr
    Middle aged
    Metabolomics
    Metabolome
    Male
    Lipoproteins
    Lipids
    Humans
    Hiv infections
    Hiv
    Female
    Dyslipidemias
    Dyslipidemia
    Cholesterol
    Art therapy
    Anti-retroviral agents
    Adult
    metabolomics
    lipoproteins
    lipids
    hiv
    dyslipidemia
    art therapy
    Saúde coletiva
    Psicología
    Peripheral vascular disease
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Ciência da computação
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
    Antropologia / arqueologia

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