Articles producció científica> Ciències Mèdiques Bàsiques

Species of Aspergillus section Aspergillus from clinical samples in the United States

  • Identification data

    Identifier: imarina:5132223
    Authors:
    Siqueira JPZ, Sutton DA, Gené J, García D, Wiederhold N, Guarro J.
    Abstract:
    The diversity of Aspergillus species in clinical samples is continuously increasing. Species under the former name Eurotium, currently accommodated in section Aspergillus of the genus Aspergillus, are xerophilic fungi widely found in the human environment and able to grow on substrates with low water activity. However, their prevalence in the clinical setting is poorly known. We have studied the presence of these species in a set of clinical samples from the United States using a multilocus sequence analysis based on the internal transcribed spacer (ITS) region of the rRNA, and fragments of the genes β-tubulin (BenA), calmodulin (CaM), and polymerase II second largest subunit (RPB2). A total of 25 isolates were studied and identified as follows: A. montevidensis (44%), A. chevalieri (36%), A. pseudoglaucus (8%), and A. costiformis (4%). A new species Aspergillus microperforatus is also proposed, which represented 8% of the isolates studied and is characterized by uniseriate conidial heads, subglobose to pyriform vesicles, rough conidia, globose to subglobose cleistothecia, and lenticular and smooth ascospores. The in vitro antifungal activity of eight clinically available antifungals was also determined against these isolates, with the echinocandins and posaconazole having the most potent activity.
  • Others:

    Author, as appears in the article.: Siqueira JPZ, Sutton DA, Gené J, García D, Wiederhold N, Guarro J.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: García Sánchez, Dania / Gené Díaz, Josepa / Guarro Artigas, Josep / ZEN SIQUEIRA, JOAO PAULO
    Keywords: Taxonomy Phylogenetic analysis Eurotium Aspergillus Antifungal susceptibility
    Abstract: The diversity of Aspergillus species in clinical samples is continuously increasing. Species under the former name Eurotium, currently accommodated in section Aspergillus of the genus Aspergillus, are xerophilic fungi widely found in the human environment and able to grow on substrates with low water activity. However, their prevalence in the clinical setting is poorly known. We have studied the presence of these species in a set of clinical samples from the United States using a multilocus sequence analysis based on the internal transcribed spacer (ITS) region of the rRNA, and fragments of the genes β-tubulin (BenA), calmodulin (CaM), and polymerase II second largest subunit (RPB2). A total of 25 isolates were studied and identified as follows: A. montevidensis (44%), A. chevalieri (36%), A. pseudoglaucus (8%), and A. costiformis (4%). A new species Aspergillus microperforatus is also proposed, which represented 8% of the isolates studied and is characterized by uniseriate conidial heads, subglobose to pyriform vesicles, rough conidia, globose to subglobose cleistothecia, and lenticular and smooth ascospores. The in vitro antifungal activity of eight clinically available antifungals was also determined against these isolates, with the echinocandins and posaconazole having the most potent activity.
    Thematic Areas: Zootecnia / recursos pesqueiros Veterinary sciences Veterinary (miscellaneous) Saúde coletiva Química Odontología Mycology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Geografía General veterinary Farmacia Engenharias iii Engenharias ii Engenharias i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 13693786
    Author's mail: dania.garcias@urv.cat josepa.gene@urv.cat
    Author identifier: 0000-0003-2397-1646 0000-0001-6195-9299
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://academic.oup.com/mmy/article/56/5/541/4372452
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Medical Mycology. 56 (5): 541-550
    APA: Siqueira JPZ, Sutton DA, Gené J, García D, Wiederhold N, Guarro J. (2018). Species of Aspergillus section Aspergillus from clinical samples in the United States. Medical Mycology, 56(5), 541-550. DOI: 10.1093/mmy/myx085
    Article's DOI: 10.1093/mmy/myx085
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Medicine (Miscellaneous),Mycology,Veterinary (Miscellaneous),Veterinary Sciences
    Taxonomy
    Phylogenetic analysis
    Eurotium
    Aspergillus
    Antifungal susceptibility
    Zootecnia / recursos pesqueiros
    Veterinary sciences
    Veterinary (miscellaneous)
    Saúde coletiva
    Química
    Odontología
    Mycology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    Geografía
    General veterinary
    Farmacia
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Biotecnología
    Biodiversidade
    Astronomia / física
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