Articles producció científica> Bioquímica i Biotecnologia

Dose-related antihypertensive properties and the corresponding mechanisms of a chicken foot hydrolysate in hypertensive rats

  • Identification data

    Identifier: imarina:5132406
    Authors:
    Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona
    Abstract:
    The antihypertensive properties of different doses of a chicken foot hydrolysate, Hpp11 and the mechanisms involved in this effect were investigated. Spontaneously hypertensive rats (SHR) were administered water, Captopril (50 mg/kg) or Hpp11 at different doses (25, 55 and 85 mg/kg), and the systolic blood pressure (SBP) was recorded. The SBP of normotensive Wistar-Kyoto (WKY) rats administered water or Hpp11 was also recorded. Additionally, plasmatic angiotensin-converting enzyme (ACE) activity was determined in the SHR administered Hpp11. Moreover, the relaxation caused by Hpp11 in isolated aortic rings from Sprague-Dawley rats was evaluated. Hpp11 exhibited antihypertensive activity at doses of 55 and 85 mg/kg, with maximum activity 6 h post-administration. At this time, no differences were found between these doses and Captopril. Initial SBP values of 55 and 85 mg/kg were recovered 24 or 8 h post-administration, respectively, 55 mg/kg being the most effective dose. At this dose, a reduction in the plasmatic ACE activity in the SHR was found. However, Hpp11 did not relax the aortic ring preparations. Therefore, ACE inhibition could be the mechanism underlying Hpp11 antihypertensive effect. Remarkably, Hpp11 did not modify SBP in WKY rats, showing that the decreased SBP effect is specific to the hypertensive state.
  • Others:

    Author, as appears in the article.: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    URV's Author/s: Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA
    Keywords: Renin Protein hydrolysate Pressure Leg bone protein Hypertension Enzyme-inhibitory peptides Endothelial dysfunction Egg-white By-products Bioavailability Bioactive peptides Angiotensin-converting enzyme Angiotensin Ace-inhibitory activity hypertension endothelial dysfunction bioactive peptides angiotensin-converting enzyme ace-inhibitory activity
    Abstract: The antihypertensive properties of different doses of a chicken foot hydrolysate, Hpp11 and the mechanisms involved in this effect were investigated. Spontaneously hypertensive rats (SHR) were administered water, Captopril (50 mg/kg) or Hpp11 at different doses (25, 55 and 85 mg/kg), and the systolic blood pressure (SBP) was recorded. The SBP of normotensive Wistar-Kyoto (WKY) rats administered water or Hpp11 was also recorded. Additionally, plasmatic angiotensin-converting enzyme (ACE) activity was determined in the SHR administered Hpp11. Moreover, the relaxation caused by Hpp11 in isolated aortic rings from Sprague-Dawley rats was evaluated. Hpp11 exhibited antihypertensive activity at doses of 55 and 85 mg/kg, with maximum activity 6 h post-administration. At this time, no differences were found between these doses and Captopril. Initial SBP values of 55 and 85 mg/kg were recovered 24 or 8 h post-administration, respectively, 55 mg/kg being the most effective dose. At this dose, a reduction in the plasmatic ACE activity in the SHR was found. However, Hpp11 did not relax the aortic ring preparations. Therefore, ACE inhibition could be the mechanism underlying Hpp11 antihypertensive effect. Remarkably, Hpp11 did not modify SBP in WKY rats, showing that the decreased SBP effect is specific to the hypertensive state.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat
    Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588
    Record's date: 2024-09-21
    Journal volume: 10
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/10/9/1295
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 10 (9):
    APA: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona (2018). Dose-related antihypertensive properties and the corresponding mechanisms of a chicken foot hydrolysate in hypertensive rats. Nutrients, 10(9), -. DOI: 10.3390/nu10091295
    Article's DOI: 10.3390/nu10091295
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Renin
    Protein hydrolysate
    Pressure
    Leg bone protein
    Hypertension
    Enzyme-inhibitory peptides
    Endothelial dysfunction
    Egg-white
    By-products
    Bioavailability
    Bioactive peptides
    Angiotensin-converting enzyme
    Angiotensin
    Ace-inhibitory activity
    hypertension
    endothelial dysfunction
    bioactive peptides
    angiotensin-converting enzyme
    ace-inhibitory activity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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