Author, as appears in the article.: Serena, Carolina; Ceperuelo-Mallafre, Victoria; Keiran, Noelia; Isabel Queipo-Ortuno, Maria; Bernal, Rosa; Gomez-Huelgas, Ricardo; Urpi-Sarda, Mireia; Sabater, Monica; Perez-Brocal, Vicente; Andres-Lacueva, Cristina; Moya, Andres; Tinahones, Francisco J; Manuel Fernandez-Real, Jose; Vendrell, Joan; Fernandez-Veledo, Sonia
Department: Medicina i Cirurgia; Ciències Mèdiques Bàsiques
URV's Author/s: Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Urpi Sarda, Mireia / Vendrell Ortega, Juan José
Keywords: Succinic acid; Sp nov.; Serum zonulin; Receptor gpr91; Prospective studies; Phylogeny; Obesity; Middle aged; Metabolites; Mediterranean diet; Marker; Male; Humans; Glucose; Gastrointestinal microbiome; Female; Emerging role; Diabetes mellitus, type 2; Cross-sectional studies; Chain fatty-acids; Biomarkers; Bacteria; Aged; Adult; Adipose-tissue
Abstract: © 2018 The Author(s). Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.
Thematic Areas: Microbiology; Medicina ii; Interdisciplinar; Geociências; Engenharias iv; Engenharias iii; Ecology, evolution, behavior and systematics; Ecology; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Biotecnología; Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17517362
Author's mail: mireia.urpi@urv.cat; victoria.ceperuelo@urv.cat; sonia.fernandez@urv.cat; jvortega@iispv.cat
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41396-018-0068-2
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Isme Journal. 12 (7): 1642-1657
APA: Serena, Carolina; Ceperuelo-Mallafre, Victoria; Keiran, Noelia; Isabel Queipo-Ortuno, Maria; Bernal, Rosa; Gomez-Huelgas, Ricardo; Urpi-Sarda, Mireia; (2018). Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.. Isme Journal, 12(7), 1642-1657. DOI: 10.1038/s41396-018-0068-2
Article's DOI: 10.1038/s41396-018-0068-2
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV