Author, as appears in the article.: Ramos-Romero S, Hereu M, Atienza L, Casas J, Taltavull N, Romeu M, Amézqueta S, Dasilva G, Medina I, Torres JL
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Romeu Ferran, Marta / Taltavull Anglada, Núria
Keywords: Weight Polyunsaturated fatty-acids Obesity Microbiota Mice Mechanisms Insulin-resistance Inflammation Induced obesity Iminosugars Iminocyclitol Gut microbiota Endotoxemia Diabetes microbiota inflammation iminosugars iminocyclitol diabetes
Abstract: The goals of this work are to test if d-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action.Wistar Kyoto rats were fed a high-fat diet supplemented with d-fagomine (or not, for comparison) or a standard diet (controls) for 24 weeks. The variables measured were fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue (AT), liver, and muscle; inflammation markers (plasma IL-6 and leptin, and liver and AT histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales, and Bifidobacteriales in feces. It was found that d-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers, and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 , and leukotriene B4 ) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales.d-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of d-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Author's mail: nuria.taltavull@urv.cat marta.romeu@urv.cat
Author identifier: 0000-0002-3340-2650 0000-0002-2131-1858
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201800373
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 62 (16): e1800373-
APA: Ramos-Romero S, Hereu M, Atienza L, Casas J, Taltavull N, Romeu M, Amézqueta S, Dasilva G, Medina I, Torres JL (2018). Functional effects of the buckwheat iminosugar d-fagomine on rats with diet-induced prediabetes.. Molecular Nutrition & Food Research, 62(16), e1800373-. DOI: 10.1002/mnfr.201800373
Article's DOI: 10.1002/mnfr.201800373
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications