Author, as appears in the article.: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S.
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bellés Mateu, Montserrat / Linares Vidal, M. Victoria
Keywords: Tlx nuclear receptor Sonic hedgehog pathway Notch pathway Neurogenesis Hippocampal neurogenesis and neuronal lineage differentiation Heterozygous mice Expression profiles of neurogenesis-related genes Dentate gyrus Behavioral effects tlx nuclear receptor notch pathway hippocampal neurogenesis and neuronal lineage differentiation expression profiles of neurogenesis-related genes behavioral effects
Abstract: Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/−). We demonstrated for the first time, that Ptch1+/− mice exhibit morphological, cellular and molecular alterations in the dentate gyrus (DG), including elongation and reduced width of the DG as well as deregulations at multiple steps during lineage progression from neural stem cells to neurons. By using stage-specific cellular markers, we detected reduction of quiescent stem cells, newborn neurons and astrocytes and accumulation of proliferating intermediate progenitors, indicative of defects in the dynamic transition among neural stages. Phenotypic alterations in Ptch1+/− mice were accompanied by expression changes in Notch pathway downstream components and TLX nuclear receptor, as well as perturbations in inflammatory and synaptic networks and mouse behavior, pointing to complex biological interactions and highlighting cooperation between Shh and Notch signaling in the regulation of neurogenesis.
Thematic Areas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16625099
Author's mail: mvictoria.linares@urv.cat montserrat.belles@urv.cat
Author identifier: 0000-0003-4170-4197 0000-0002-9282-2989
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fnmol.2018.00168/full
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Molecular Neuroscience. 11 (168): 168-
APA: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S. (2018). Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.. Frontiers In Molecular Neuroscience, 11(168), 168-. DOI: 10.3389/fnmol.2018.00168
Article's DOI: 10.3389/fnmol.2018.00168
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV