Articles producció científica> Ciències Mèdiques Bàsiques

Review of the treatment of Graves' ophthalmopathy: The role of the new radiation techniques

  • Identification data

    Identifier: imarina:5132742
    Authors:
    San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P.
    Abstract:
    Graves ophthalmopathy (GO) is an autoimmune disorder and the most frequent extrathyroidal manifestation of Graves' disease. GO is an inflammatory process leading to an increased volume of the extraocular muscles and orbital connective and adipose tissues associated with multiple histopathological changes. Despite recent progress in the understanding of its pathogenesis, GO often remains a major diagnostic and therapeutic challenge. It has become increasingly important to classify patients into categories based on disease severity and activity. Low doses of radiotherapy (RT) have demonstrated a benefit in the treatment of moderate-to-severe GO with very few side effects. New RT techniques deliver a more conformal dose distribution to the target and decrease the dose to normal healthy tissue minimizing the risk of side effects. In this review we briefly analyzed the pathogenesis of GO and discussed the most relevant therapeutic approaches, with particular emphasis in the new RT technics. Appropriately designed and powered clinical studies are necessary to determine the most effective treatment with the lowest risk of side effects.
  • Others:

    Author, as appears in the article.: San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell
    Keywords: Toxicity Radiotherapy Graves’ opthalmopathy radiotherapy graves’ opthalmopathy
    Abstract: Graves ophthalmopathy (GO) is an autoimmune disorder and the most frequent extrathyroidal manifestation of Graves' disease. GO is an inflammatory process leading to an increased volume of the extraocular muscles and orbital connective and adipose tissues associated with multiple histopathological changes. Despite recent progress in the understanding of its pathogenesis, GO often remains a major diagnostic and therapeutic challenge. It has become increasingly important to classify patients into categories based on disease severity and activity. Low doses of radiotherapy (RT) have demonstrated a benefit in the treatment of moderate-to-severe GO with very few side effects. New RT techniques deliver a more conformal dose distribution to the target and decrease the dose to normal healthy tissue minimizing the risk of side effects. In this review we briefly analyzed the pathogenesis of GO and discussed the most relevant therapeutic approaches, with particular emphasis in the new RT technics. Appropriately designed and powered clinical studies are necessary to determine the most effective treatment with the lowest risk of side effects.
    Thematic Areas: Ophthalmology Medicina iii Medicina i
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 13194534
    Author's mail: meritxell.arenas@urv.cat
    Author identifier: 0000-0003-0815-2570
    Record's date: 2023-04-01
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1319453417301133
    Papper original source: Saudi Journal Of Ophthalmology. 32 (2): 139-145
    APA: San Miguel I, Arenas M, Carmona R, Rutllan J, Medina-Rivero F, Lara P. (2018). Review of the treatment of Graves' ophthalmopathy: The role of the new radiation techniques. Saudi Journal Of Ophthalmology, 32(2), 139-145. DOI: 10.1016/j.sjopt.2017.09.003
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.sjopt.2017.09.003
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Ophthalmology
    Toxicity
    Radiotherapy
    Graves’ opthalmopathy
    radiotherapy
    graves’ opthalmopathy
    Ophthalmology
    Medicina iii
    Medicina i
  • Documents:

  • Cerca a google

    Search to google scholar