Articles producció científica> Medicina i Cirurgia

Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance - Supercontrollers

  • Identification data

    Identifier: imarina:5132823
    Authors:
    Dominguez-Molina, BeatrizFerrando-Martinez, SaraTarancon-Diez, LauraHernandez-Quero, JoseGenebat, MiguelVidal, FranciscoAngeles Munoz-Fernandez, MaLeal, ManuelKoup, RichardRuiz-Mateos, Ezequiel
    Abstract:
    HIV-elite controllers are a minority group of HIV-infected patients with the ability to maintain undetectable HIV viremia for long time periods without antiretroviral treatment. A small group of HIV-controllers are also able to spontaneously clear the hepatitis C virus (HCV) whom we can refer to as supercontrollers. There are no studies that explore immune correlates looking for the mechanisms implicated in this extraordinary phenomenon. Herein, we have analyzed HCV- and HIV-specific T-cell responses, as well as T, dendritic and NK cell phenotypes. The higher HCV-specific CD4 T-cell polyfunctionality, together with a low activation and exhaustion T-cell phenotype was found in supercontrollers. In addition, the frequency of CD8 CD161high T-cells was related with HIV- and HCV-specific T-cells polyfunctionality. Interesting features regarding NK and plasmacytoid dendritic cells (pDCs) were found. The study of the supercontroller's immune response, subjects that spontaneously controls both chronic viral infections, could provide further insights into virus-specific responses needed to develop immunotherapeutic strategies in the setting of HIV cure or HCV vaccination.
  • Others:

    Author, as appears in the article.: Dominguez-Molina, Beatriz; Ferrando-Martinez, Sara; Tarancon-Diez, Laura; Hernandez-Quero, Jose; Genebat, Miguel; Vidal, Francisco; Angeles Munoz-Fernandez, Ma; Leal, Manuel; Koup, Richard; Ruiz-Mateos, Ezequiel
    Department: Medicina i Cirurgia
    URV's Author/s: Vidal Marsal, Francisco
    Keywords: Viral clearance T-cells Supercontrollers Spontaneous clearance Responses Pdcs Nonstructural protein-3 Nk Mutational escape Infection Hiv Hepatitis-c virus Hcv Dendritic cells Controllers Class-ii alleles Cd8(+) t-cells Cd4(+) t-cells spontaneous clearance pdcs nk hiv hcv controllers
    Abstract: HIV-elite controllers are a minority group of HIV-infected patients with the ability to maintain undetectable HIV viremia for long time periods without antiretroviral treatment. A small group of HIV-controllers are also able to spontaneously clear the hepatitis C virus (HCV) whom we can refer to as supercontrollers. There are no studies that explore immune correlates looking for the mechanisms implicated in this extraordinary phenomenon. Herein, we have analyzed HCV- and HIV-specific T-cell responses, as well as T, dendritic and NK cell phenotypes. The higher HCV-specific CD4 T-cell polyfunctionality, together with a low activation and exhaustion T-cell phenotype was found in supercontrollers. In addition, the frequency of CD8 CD161high T-cells was related with HIV- and HCV-specific T-cells polyfunctionality. Interesting features regarding NK and plasmacytoid dendritic cells (pDCs) were found. The study of the supercontroller's immune response, subjects that spontaneously controls both chronic viral infections, could provide further insights into virus-specific responses needed to develop immunotherapeutic strategies in the setting of HIV cure or HCV vaccination.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16643224
    Author's mail: francesc.vidal@urv.cat
    Author identifier: 0000-0002-6692-6186
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fimmu.2018.02897/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Immunology. 9 (2897): 2897-
    APA: Dominguez-Molina, Beatriz; Ferrando-Martinez, Sara; Tarancon-Diez, Laura; Hernandez-Quero, Jose; Genebat, Miguel; Vidal, Francisco; Angeles Munoz-Fern (2018). Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance - Supercontrollers. Frontiers In Immunology, 9(2897), 2897-. DOI: 10.3389/fimmu.2018.02897
    Article's DOI: 10.3389/fimmu.2018.02897
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Immunology,Immunology and Allergy
    Viral clearance
    T-cells
    Supercontrollers
    Spontaneous clearance
    Responses
    Pdcs
    Nonstructural protein-3
    Nk
    Mutational escape
    Infection
    Hiv
    Hepatitis-c virus
    Hcv
    Dendritic cells
    Controllers
    Class-ii alleles
    Cd8(+) t-cells
    Cd4(+)
    t-cells
    spontaneous clearance
    pdcs
    nk
    hiv
    hcv
    controllers
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Immunology and allergy
    Immunology
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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