Articles producció científica> Medicina i Cirurgia

Rituximab in treatment-resistant CIDP with antibodies against paranodal proteins

  • Identification data

    Identifier: imarina:5132929
    Authors:
    Querol, LuisRojas-Garcia, RicardDiaz-Manera, JordiBarcena, JosebaPardo, JulioOrtega-Moreno, AngelSedano, Maria JoseSero-Ballesteros, LaiaCarvajal, AlejandraOrtiz, NicolauGallardo, EduardIlla, Isabel
    Abstract:
    To describe the response to rituximab in patients with treatment-resistant chronic inflammatory demyelinating polyneuropathy (CIDP) with antibodies against paranodal proteins and correlate the response with autoantibody titers.Patients with CIDP and IgG4 anti-contactin-1 (CNTN1) or anti-neurofascin-155 (NF155) antibodies who were resistant to IV immunoglobulin and corticosteroids were treated with rituximab and followed prospectively. Immunocytochemistry was used to detect anti-CNTN1 and anti-NF155 antibodies and ELISA with human recombinant CNTN1 and NF155 proteins was used to determine antibody titers.Two patients had a marked improvement; another patient improved slightly after 10 years of stable, severe disease; and the fourth patient had an ischemic stroke unrelated to treatment and was lost to follow-up. Autoantibodies decreased in all patients after rituximab treatment.Rituximab treatment is an option for patients with CIDP with IgG4 anti-CNTN1/NF155 antibodies who are resistant to conventional therapies.This study provides Class IV evidence that rituximab is effective for patients with treatment-resistant CIDP with IgG4 anti-CNTN1 or anti-NF155 antibodies.
  • Others:

    Author, as appears in the article.: Querol, Luis; Rojas-Garcia, Ricard; Diaz-Manera, Jordi; Barcena, Joseba; Pardo, Julio; Ortega-Moreno, Angel; Sedano, Maria Jose; Sero-Ballesteros, Laia; Carvajal, Alejandra; Ortiz, Nicolau; Gallardo, Eduard; Illa, Isabel;
    Department: Medicina i Cirurgia
    URV's Author/s: Ortiz Castellón, Nicolau Antoni
    Abstract: To describe the response to rituximab in patients with treatment-resistant chronic inflammatory demyelinating polyneuropathy (CIDP) with antibodies against paranodal proteins and correlate the response with autoantibody titers.Patients with CIDP and IgG4 anti-contactin-1 (CNTN1) or anti-neurofascin-155 (NF155) antibodies who were resistant to IV immunoglobulin and corticosteroids were treated with rituximab and followed prospectively. Immunocytochemistry was used to detect anti-CNTN1 and anti-NF155 antibodies and ELISA with human recombinant CNTN1 and NF155 proteins was used to determine antibody titers.Two patients had a marked improvement; another patient improved slightly after 10 years of stable, severe disease; and the fourth patient had an ischemic stroke unrelated to treatment and was lost to follow-up. Autoantibodies decreased in all patients after rituximab treatment.Rituximab treatment is an option for patients with CIDP with IgG4 anti-CNTN1/NF155 antibodies who are resistant to conventional therapies.This study provides Class IV evidence that rituximab is effective for patients with treatment-resistant CIDP with IgG4 anti-CNTN1 or anti-NF155 antibodies.
    Thematic Areas: Neurosciences Neurology (clinical) Neurology Medicine (all) Clinical neurology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nicolauantoni.ortiz@urv.cat
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://nn.neurology.org/content/2/5/e149.short
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Neurology-Neuroimmunology & Neuroinflammation. 2 (5): e149-
    APA: Querol, Luis; Rojas-Garcia, Ricard; Diaz-Manera, Jordi; Barcena, Joseba; Pardo, Julio; Ortega-Moreno, Angel; Sedano, Maria Jose; Sero-Ballesteros, Lai (2015). Rituximab in treatment-resistant CIDP with antibodies against paranodal proteins. Neurology-Neuroimmunology & Neuroinflammation, 2(5), e149-. DOI: 10.1212/NXI.0000000000000149
    Article's DOI: 10.1212/NXI.0000000000000149
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Clinical Neurology,Neurology,Neurology (Clinical),Neurosciences
    Neurosciences
    Neurology (clinical)
    Neurology
    Medicine (all)
    Clinical neurology
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