Articles producció científica> Medicina i Cirurgia

Patients with systemic lupus erythematosus show an increased arterial stiffness that is predicted by IgM anti-β[2] -Glycoprotein I and small dense high-density lipoprotein particles

  • Identification data

    Identifier: imarina:5133028
    Authors:
    Parra, SLopez-Dupla, MIbarretxe, Dde las Heras, MAmigó, NCatalà, ABenavent, MGarcés, ENavarro, ACastro, A
    Abstract:
    Objective To investigate the metabolic and immunologic factors associated with the presence of central arterial stiffness as measured by the augmentation index (AIx). Methods We conducted a cross-sectional study of 69 female patients with systemic lupus erythematosus (SLE) compared with a control group of 34 healthy women. The anthropometrical variables, the vascular studies, and the analytic data were obtained the same day. The AIx was assessed by peripheral arterial tonometry. The analysis of lipoprotein populations was performed using nuclear magnetic resonance (NMR) spectroscopy. Results Arterial stiffness was increased in patients with SLE compared with control subjects (mean +/- SD 20.30 +/- 21.54% versus 10.84 +/- 11.51%; P = 0.0021). Values for the AIx were correlated with the Framingham risk score (r = 0.481, P < 0.001), carotid intima-media thickness (r = 0.503, P < 0.001), systolic blood pressure (r = 0.270, P < 0.001), and age (r = 0.365, P < 0.001). Patients receiving antimalarial drugs had a lower AIx (mean +/- SD 11.74 +/- 11.28% versus 24.97 +/- 20.63%; P = 0.024). The AIx was correlated with the atherogenic lipoproteins analyzed by NMR. The immunologic variables associated with the AIx were C4 (r = 0.259, P = 0.046) and IgM anti-beta(2)-glycoprotein I (IgM anti-beta(2)GPI) (r = 0.284, P = 0.284). In the multivariate analysis, age (beta = 0.347, 95% confidence interval [95% CI] 0.020-0.669, P = 0.035), IgM beta(2)GPI (beta = 0.321, 95% CI 0.024-0.618, P = 0.035) and small dense high-density lipoprotein (HDL) particles (beta = 1.288, 95% CI 0.246-2.329, P = 0.017) predicted the AIx. Conclusion SLE patients had increased arterial stiffness compared with healthy control subjects. Arterial stiffness was decreased in patients treated with antimalarial drugs.
  • Others:

    Author, as appears in the article.: Parra, S; Lopez-Dupla, M; Ibarretxe, D; de las Heras, M; Amigó, N; Català, A; Benavent, M; Garcés, E; Navarro, A; Castro, A
    Department: Medicina i Cirurgia
    URV's Author/s: Castro Salomó, Antoni / Ibarretxe Gerediaga, Daiana / López Dupla, Jesús Miguel / Parra Pérez, Sandra
    Keywords: Vascular stiffness Risk Recommendations Intima-media thickness Independent predictor Dysfunction Disease-activity Damage Cholesterol Atherosclerosis
    Abstract: Objective To investigate the metabolic and immunologic factors associated with the presence of central arterial stiffness as measured by the augmentation index (AIx). Methods We conducted a cross-sectional study of 69 female patients with systemic lupus erythematosus (SLE) compared with a control group of 34 healthy women. The anthropometrical variables, the vascular studies, and the analytic data were obtained the same day. The AIx was assessed by peripheral arterial tonometry. The analysis of lipoprotein populations was performed using nuclear magnetic resonance (NMR) spectroscopy. Results Arterial stiffness was increased in patients with SLE compared with control subjects (mean +/- SD 20.30 +/- 21.54% versus 10.84 +/- 11.51%; P = 0.0021). Values for the AIx were correlated with the Framingham risk score (r = 0.481, P < 0.001), carotid intima-media thickness (r = 0.503, P < 0.001), systolic blood pressure (r = 0.270, P < 0.001), and age (r = 0.365, P < 0.001). Patients receiving antimalarial drugs had a lower AIx (mean +/- SD 11.74 +/- 11.28% versus 24.97 +/- 20.63%; P = 0.024). The AIx was correlated with the atherogenic lipoproteins analyzed by NMR. The immunologic variables associated with the AIx were C4 (r = 0.259, P = 0.046) and IgM anti-beta(2)-glycoprotein I (IgM anti-beta(2)GPI) (r = 0.284, P = 0.284). In the multivariate analysis, age (beta = 0.347, 95% confidence interval [95% CI] 0.020-0.669, P = 0.035), IgM beta(2)GPI (beta = 0.321, 95% CI 0.024-0.618, P = 0.035) and small dense high-density lipoprotein (HDL) particles (beta = 1.288, 95% CI 0.246-2.329, P = 0.017) predicted the AIx. Conclusion SLE patients had increased arterial stiffness compared with healthy control subjects. Arterial stiffness was decreased in patients treated with antimalarial drugs. Age, IgM beta(2)GPI, and the number of small dense HDL particles predicted the AIx.
    Thematic Areas: Saúde coletiva Rheumatology Rehabilitation Psicología Medicina iii Medicina ii Medicina i General medicine Farmacia Educação física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2151464X
    Author's mail: daiana.ibarretxe@urv.cat jesusmiguel.lopez@urv.cat antoni.castro@urv.cat sandra.parra@urv.cat
    Author identifier: 0000-0002-9141-2523 0000-0001-5441-6333 0000-0001-9363-6574
    Last page: 125
    Record's date: 2024-02-10
    Journal volume: 71
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23594
    Papper original source: Arthritis Care & Research. 71 (1): 116-125
    APA: Parra, S; Lopez-Dupla, M; Ibarretxe, D; de las Heras, M; Amigó, N; Català, A; Benavent, M; Garcés, E; Navarro, A; Castro, A (2019). Patients with systemic lupus erythematosus show an increased arterial stiffness that is predicted by IgM anti-β[2] -Glycoprotein I and small dense high-density lipoprotein particles. Arthritis Care & Research, 71(1), 116-125. DOI: 10.1002/acr.23594
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1002/acr.23594
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    First page: 116
    Publication Type: Journal Publications
  • Keywords:

    Rehabilitation,Rheumatology
    Vascular stiffness
    Risk
    Recommendations
    Intima-media thickness
    Independent predictor
    Dysfunction
    Disease-activity
    Damage
    Cholesterol
    Atherosclerosis
    Saúde coletiva
    Rheumatology
    Rehabilitation
    Psicología
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Educação física
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