Articles producció científica> Medicina i Cirurgia

Effects of early nutrition on the infant metabolome.

  • Identification data

    Identifier: imarina:5133059
    Authors:
    Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group.
    Abstract:
    Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.
  • Others:

    Author, as appears in the article.: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group.
    Department: Medicina i Cirurgia
    URV's Author/s: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
    Keywords: Zero hunger
    Abstract: Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.
    Thematic Areas: Pediatrics, perinatology and child health Nutrition and dietetics Medicine (miscellaneous) Medicine (all) Food science
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: veronica.luque@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Author identifier: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
    Record's date: 2024-11-16
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.karger.com/Article/Abstract/439491
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nestle Nutrition Institute Workshop Series. 85 89-100
    APA: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesi (2016). Effects of early nutrition on the infant metabolome.. Nestle Nutrition Institute Workshop Series, 85(), 89-100. DOI: 10.1159/000439491
    Article's DOI: 10.1159/000439491
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Medicine (Miscellaneous),Nutrition and Dietetics,Pediatrics, Perinatology and Child Health
    Zero hunger
    Pediatrics, perinatology and child health
    Nutrition and dietetics
    Medicine (miscellaneous)
    Medicine (all)
    Food science
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