Author, as appears in the article.: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J; Guimera, Roger; Garcia-Rico, Eduardo; Alvarez-Puebla, Ramon A
Department: Enginyeria Química
URV's Author/s: Alvarez Puebla, Ramon Angel / Guerrini, Luca / Guimera Manrique, Roger
Keywords: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu
Abstract: In this manuscript, we demonstrate the applicability of a metabolic liquid biopsy for the monitoring and staging of patients with lung cancer. This method provides an unbiased detection strategy to establish a more precise correlation between CTC quantification and the actual burden of disease, therefore improving the accuracy of staging based on current imaging techniques. Also, by applying statistical analysis techniques and probabilistic models to the metabolic status and distribution of peripheral blood mononuclear cell (PBMC) populations 'perturbed' by the presence of CTCs, a new category of adaptive metabolic pattern biomarker (AMPB) is described and unambiguously correlated to the different clinical stages of the patients. In fact, this strategy allows for classification of different categories of disease within a single stage (stage IV) before computed tomography (CT) and positron emission tomography (PET) scans and with lower uncertainty.
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2397-768X
Author's mail: roger.guimera@urv.cat ramon.alvarez@urv.cat luca.guerrini@urv.cat
Author identifier: 0000-0002-3597-4310 0000-0003-4770-5756 0000-0002-2925-1562
Record's date: 2024-10-26
Journal volume: 2
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41698-018-0059-9
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Npj Precision Oncology. 2 (1): 16-
APA: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J; Guimera, Roger; Garcia-Rico, Eduardo; (2018). Adaptive metabolic pattern biomarker for disease monitoring and staging of lung cancer with liquid biopsy. Npj Precision Oncology, 2(1), 16-. DOI: 10.1038/s41698-018-0059-9
Article's DOI: 10.1038/s41698-018-0059-9
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
First page: Article number 16
Publication Type: Journal Publications
Repositori URV