Author, as appears in the article.: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Toledo, Estefania; Dennis, Courtney; Deik, Amy; Clish, Clary; Razquin, Cristina; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Fiol, Miquel; Lapetra, Jose; Ruano, Cristina; Liang, Liming; Martinez-Gonzalez, Miguel A; Hu, Frank B; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Serum-lipids Risk Responses Predimed Plasma Nutritional epidemiology Middle aged Metabolomics Metaanalysis Male Identification Humans Female Drinking Cross-sectional studies Cohort studies Coffee Case-control studies Caffeine ingestion Caffeine Biomarkers Aged Acid predimed metabolomics coffee caffeine
Abstract: Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (≥50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Journal volume: 11
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/11/5/1032
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 11 (5): 1032-
APA: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Toledo, Estefania; Dennis, Cour (2019). Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients, 11(5), 1032-. DOI: 10.3390/nu11051032
Article's DOI: 10.3390/nu11051032
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications