Articles producció científica> Bioquímica i Biotecnologia

Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial.

  • Identification data

    Identifier: imarina:5461209
    Handle: https://hdl.handle.net/20.500.11797/imarina5461209
    Authors:
    Abete I, Konieczna J, Zulet MA, Galmés-Panades AM, Ibero-Baraibar I, Babio N, Estruch R, Vidal J, Toledo E, Razquin C, Bartolomé R, Díaz-Lopez A, Fiol M, Casas R, Vera J, Buil-Cosiales P, Pintó X, Corbella E, Portillo MP, de Paz JA, Martín V, Daimiel L, Goday A, Rosique-Esteban N, Salas-Salvadó J, Romaguera D, Martínez JA, PREDIMED-PLUS Investigators
    Abstract:
    © 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C cons

  • Others:

    Author, as appears in the article.: Abete I, Konieczna J, Zulet MA, Galmés-Panades AM, Ibero-Baraibar I, Babio N, Estruch R, Vidal J, Toledo E, Razquin C, Bartolomé R, Díaz-Lopez A, Fiol M, Casas R, Vera J, Buil-Cosiales P, Pintó X, Corbella E, Portillo MP, de Paz JA, Martín V, Daimiel L, Goday A, Rosique-Esteban N, Salas-Salvadó J, Romaguera D, Martínez JA, PREDIMED-PLUS Investigators
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Díaz López, Andres / ROSIQUE ESTEBAN, NÚRIA / Salas Salvadó, Jorge
    Keywords: Visceral fat Systemic inflammation Sarcopenic index Physical activity Mediterranean diet score Leucocyte count
    Abstract: © 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance. Conclusions: Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia.
    Thematic Areas: Saúde coletiva Physiology (medical) Orthopedics and sports medicine Nutrição Medicine, general & internal Medicina iii Medicina ii Medicina i Interdisciplinar Geriatrics & gerontology Engenharias iv Engenharias ii Educação física Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 21905991
    Author's mail: andres.diaz@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-7500-5629 0000-0003-3527-5277 0000-0003-2700-7459
    Record's date: 2024-04-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Papper original source: Journal Of Cachexia Sarcopenia And Muscle. 10 (5): 974-984
    APA: Abete I, Konieczna J, Zulet MA, Galmés-Panades AM, Ibero-Baraibar I, Babio N, Estruch R, Vidal J, Toledo E, Razquin C, Bartolomé R, Díaz-Lopez A, Fiol (2019). Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial.. Journal Of Cachexia Sarcopenia And Muscle, 10(5), 974-984. DOI: 10.1002/jcsm.12442
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications

  • Keywords:

    Geriatrics & Gerontology,Medicine, General & Internal,Orthopedics and Sports Medicine,Physiology (Medical)
    Visceral fat
    Systemic inflammation
    Sarcopenic index
    Physical activity
    Mediterranean diet score
    Leucocyte count
    Saúde coletiva
    Physiology (medical)
    Orthopedics and sports medicine
    Nutrição
    Medicine, general & internal
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geriatrics & gerontology
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología

  • Documents:

    DocumentPrincipal

  • Cerca a google

    Search to google scholar