Articles producció científica> Bioquímica i Biotecnologia

Grape seed proanthocyanidins improve white adipose tissue expansion during diet-induced obesity development in rats

  • Identification data

    Identifier: imarina:5610864
    Authors:
    Pascual-Serrano ABladé CSuárez MArola-Arnal A
    Abstract:
    © 2018 by the authors. Licensee MDPI, Basel, Switzerland. The development of metabolic complications associated with obesity has been correlated with a failure of white adipose tissue (WAT) to expand. Our group has previously reported that a 12-week administration of grape seed proanthocyanidin extract (GSPE) together with an obesogenic diet mitigated the development of cardiometabolic complications in rats. Using the same cohort of animals, we aim to elucidate whether the prevention of cardiometabolic complications by proanthocyanidins is produced by a healthier expansion of visceral WAT and/or an induction of the browning of WAT. For this, adipocyte size and number in retroperitoneal WAT (rWAT) were determined by histological analyses, and the gene expression levels of markers of adipogenesis, browning, and WAT functionality were quantified by RT-qPCR. The long-term administration of GSPE together with an obesogenic diet expanded rWAT via an increase in the adipocyte number and a preventive decrease in the adipocyte size in a dose-dependent manner. At the molecular level, GSPE seems to induce WAT adipogenesis through the upregulation of peroxisome proliferator-activated receptor (Pparγ) in a Sirtuin 1 (Sirt1)-dependent manner. In conclusion, the healthier visceral WAT expansion induced by proanthocyanidins supplementation may explain the improvement in the cardiometabolic risks associated with obesogenic diets.
  • Others:

    Author, as appears in the article.: Pascual-Serrano A; Bladé C; Suárez M; Arola-Arnal A
    Department: Bioquímica i Biotecnologia
    e-ISSN: 1422-0067
    URV's Author/s: Arola Arnal, Anna / BLADÉ SEGARRA, MARIA CINTA / PASCUAL SERRANO, AÏDA / Suárez Recio, Manuel
    Keywords: Resveratrol Ppar-gamma Polyphenols Polyphenol Mice Metabolic syndrome Hypertrophy Hyperplasia High-fat Gene-expression Flavonoids Brown Adipogenesis Adipocyte Activated receptor-gamma 3t3-l1 cells hypertrophy hyperplasia flavonoids adipogenesis adipocyte
    Abstract: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. The development of metabolic complications associated with obesity has been correlated with a failure of white adipose tissue (WAT) to expand. Our group has previously reported that a 12-week administration of grape seed proanthocyanidin extract (GSPE) together with an obesogenic diet mitigated the development of cardiometabolic complications in rats. Using the same cohort of animals, we aim to elucidate whether the prevention of cardiometabolic complications by proanthocyanidins is produced by a healthier expansion of visceral WAT and/or an induction of the browning of WAT. For this, adipocyte size and number in retroperitoneal WAT (rWAT) were determined by histological analyses, and the gene expression levels of markers of adipogenesis, browning, and WAT functionality were quantified by RT-qPCR. The long-term administration of GSPE together with an obesogenic diet expanded rWAT via an increase in the adipocyte number and a preventive decrease in the adipocyte size in a dose-dependent manner. At the molecular level, GSPE seems to induce WAT adipogenesis through the upregulation of peroxisome proliferator-activated receptor (Pparγ) in a Sirtuin 1 (Sirt1)-dependent manner. In conclusion, the healthier visceral WAT expansion induced by proanthocyanidins supplementation may explain the improvement in the cardiometabolic risks associated with obesogenic diets.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14220067
    Author's mail: manuel.suarez@urv.cat anna.arola@urv.cat
    Author identifier: 0000-0003-0122-8253 0000-0001-6529-1345
    Record's date: 2024-09-07
    Journal volume: 19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/19/9/2632
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 19 (9):
    APA: Pascual-Serrano A; Bladé C; Suárez M; Arola-Arnal A (2018). Grape seed proanthocyanidins improve white adipose tissue expansion during diet-induced obesity development in rats. International Journal Of Molecular Sciences, 19(9), -. DOI: 10.3390/ijms19092632
    Article's DOI: 10.3390/ijms19092632
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Resveratrol
    Ppar-gamma
    Polyphenols
    Polyphenol
    Mice
    Metabolic syndrome
    Hypertrophy
    Hyperplasia
    High-fat
    Gene-expression
    Flavonoids
    Brown
    Adipogenesis
    Adipocyte
    Activated receptor-gamma
    3t3-l1 cells
    hypertrophy
    hyperplasia
    flavonoids
    adipogenesis
    adipocyte
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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