Articles producció científica> Química Analítica i Química Orgànica

Ionophore-based optical sensor for urine creatinine determination

  • Identification data

    Identifier: imarina:5611015
    Authors:
    Erenas MOrtiz-Gómez IDe Orbe-Payá IHernández-Alonso DBallester PBlondeau PAndrade FSalinas-Castillo ACapitán-Vallvey L
    Abstract:
    © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
  • Others:

    Author, as appears in the article.: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L
    Department: Química Analítica i Química Orgànica
    URV's Author/s: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
    Project code: CTQ2016-77128-R
    Keywords: Spectrometry Optode Host?guest chemistry Disposable sensor Calix[6]pyrrole Biofluids optode host?guest chemistry disposable sensor calix[6]pyrrole biofluids
    Abstract: © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
    Thematic Areas: Process chemistry and technology Nanoscience & nanotechnology Instrumentation Fluid flow and transfer processes Engenharias iii Chemistry, multidisciplinary Chemistry, analytical Bioengineering
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 23793694
    Author's mail: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
    Author identifier: 0000-0003-1331-5055 0000-0003-1199-2837
    Record's date: 2023-02-18
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://pubs.acs.org/doi/10.1021/acssensors.8b01378
    Funding program: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
    Papper original source: Acs Sensors. 4 (2): 421-426
    APA: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L (2019). Ionophore-based optical sensor for urine creatinine determination. Acs Sensors, 4(2), 421-426. DOI: 10.1021/acssensors.8b01378
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acronym: HOMESENS
    Article's DOI: 10.1021/acssensors.8b01378
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Funding program action: Proyecto de I+D
    Publication Type: Journal Publications
  • Keywords:

    Bioengineering,Chemistry, Analytical,Chemistry, Multidisciplinary,Fluid Flow and Transfer Processes,Instrumentation,Nanoscience & Nanotechnology,Process Chemistry and Technology
    Spectrometry
    Optode
    Host?guest chemistry
    Disposable sensor
    Calix[6]pyrrole
    Biofluids
    optode
    host?guest chemistry
    disposable sensor
    calix[6]pyrrole
    biofluids
    Process chemistry and technology
    Nanoscience & nanotechnology
    Instrumentation
    Fluid flow and transfer processes
    Engenharias iii
    Chemistry, multidisciplinary
    Chemistry, analytical
    Bioengineering
  • Documents:

  • Cerca a google

    Search to google scholar