Author, as appears in the article.: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L
Department: Química Analítica i Química Orgànica
URV's Author/s: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
Project code: CTQ2016-77128-R
Keywords: Spectrometry Optode Host?guest chemistry Disposable sensor Calix[6]pyrrole Biofluids optode host?guest chemistry disposable sensor calix[6]pyrrole biofluids
Abstract: © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
Thematic Areas: Process chemistry and technology Nanoscience & nanotechnology Instrumentation Fluid flow and transfer processes Engenharias iii Chemistry, multidisciplinary Chemistry, analytical Bioengineering
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 23793694
Author's mail: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
Author identifier: 0000-0003-1331-5055 0000-0003-1199-2837
Record's date: 2023-02-18
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/acssensors.8b01378
Funding program: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
Papper original source: Acs Sensors. 4 (2): 421-426
APA: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L (2019). Ionophore-based optical sensor for urine creatinine determination. Acs Sensors, 4(2), 421-426. DOI: 10.1021/acssensors.8b01378
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Acronym: HOMESENS
Article's DOI: 10.1021/acssensors.8b01378
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Funding program action: Proyecto de I+D
Publication Type: Journal Publications