Articles producció científica> Medicina i Cirurgia

Negative effect of a low-carbohydrate, high-protein, high-fat diet on small peripheral artery reactivity in patients with increased cardiovascular risk

  • Identification data

    Identifier: imarina:561747
    Authors:
    IBARRECHE GUEREDIAGA, DAIANAARAGONÈS BARGALLÓ, GEMMAMerino, JordiKones, RichardFerre, RaimonPlana, NuriaGirona, JosefaAragones, GemmaIbarretxe, DaianaHeras, MercedesMasana, Luis
    Abstract:
    Low-carbohydrate diets have become increasingly popular for weight loss. Although they may improve some metabolic markers, particularly in type 2 diabetes mellitus (T2D) or the metabolic syndrome (MS), their net effect on arterial wall function remains unclear. The objective was to evaluate the relation between dietary macronutrient composition and the small artery reactive hyperaemia index (saRHI), a marker of small artery endothelial function, in a cohort of patients at increased cardiovascular (CV) risk. The present cross-sectional study included 247 patients. Diet was evaluated by a 3-d food-intake register and reduced to a novel low-carbohydrate diet score (LCDS). Physical examination, demographic, biochemical and anthropometry parameters were recorded, and the saRHI was measured in each patient. Individuals in the lowest LCDS quartile (Q1, 45 % carbohydrate; 20 % protein; 32 % fat) had higher saRHI values than those in the top quartile (Q4, 29 % carbohydrate, 24 % protein, 40 % fat; 1.66 (sd 0.41) v. 1.52 (sd 0.22), P= 0.037). These results were particularly strong in patients with the MS (Q1 = 1.82 (sd 0.32) v. Q4 = 1.61 (sd 027); P= 0.021) and T2D (Q1 = 1.78 (sd 0.31) v. Q4 = 1.62 (sd 0.35); P= 0.011). Multivariate analysis demonstrated that individuals in the highest LCDS quartile had a significantly negative coefficient of saRHI, which was independent of confounders (OR -0.85; 95 % CI 0.19, 0.92; P= 0.031). These findings suggest that a dietary pattern characterised by a low amount of carbohydrate, but high amounts of protein and fat, is associated with a poorer small artery vascular reactivity in patients with increased CV risk.
  • Others:

    Author, as appears in the article.: IBARRECHE GUEREDIAGA, DAIANA; ARAGONÈS BARGALLÓ, GEMMA; Merino, Jordi; Kones, Richard; Ferre, Raimon; Plana, Nuria; Girona, Josefa; Aragones, Gemma; Ibarretxe, Daiana; Heras, Mercedes; Masana, Luis
    Department: Universitat Rovira i Virgili Oficina de Suport a la Recerca - Becaris Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: ARAGONÈS BARGALLÓ, GEMMA / FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / MERINO RIBAS, JORDI / Plana Gil, Núria
    Keywords: Abdominal obesity Adult Aged Cardiovascular risk Cohort studies Complications Cross-sectional relations Cross-sectional studies Diabetes mellitus, type 2 Diet therapy Disease Endothelial function Endothelium, vascular Etiology Female Health Humans Life-style changes Low-carbohydrate diets Male Markers Metabolic syndrome Metabolic syndrome x Middle aged Overweight Risk factors Self care Spain Type 2 diabetes mellitus Vascular function Very-low-carbohydrate Weight-loss
    Abstract: Low-carbohydrate diets have become increasingly popular for weight loss. Although they may improve some metabolic markers, particularly in type 2 diabetes mellitus (T2D) or the metabolic syndrome (MS), their net effect on arterial wall function remains unclear. The objective was to evaluate the relation between dietary macronutrient composition and the small artery reactive hyperaemia index (saRHI), a marker of small artery endothelial function, in a cohort of patients at increased cardiovascular (CV) risk. The present cross-sectional study included 247 patients. Diet was evaluated by a 3-d food-intake register and reduced to a novel low-carbohydrate diet score (LCDS). Physical examination, demographic, biochemical and anthropometry parameters were recorded, and the saRHI was measured in each patient. Individuals in the lowest LCDS quartile (Q1, 45 % carbohydrate; 20 % protein; 32 % fat) had higher saRHI values than those in the top quartile (Q4, 29 % carbohydrate, 24 % protein, 40 % fat; 1.66 (sd 0.41) v. 1.52 (sd 0.22), P= 0.037). These results were particularly strong in patients with the MS (Q1 = 1.82 (sd 0.32) v. Q4 = 1.61 (sd 027); P= 0.021) and T2D (Q1 = 1.78 (sd 0.31) v. Q4 = 1.62 (sd 0.35); P= 0.011). Multivariate analysis demonstrated that individuals in the highest LCDS quartile had a significantly negative coefficient of saRHI, which was independent of confounders (OR -0.85; 95 % CI 0.19, 0.92; P= 0.031). These findings suggest that a dietary pattern characterised by a low amount of carbohydrate, but high amounts of protein and fat, is associated with a poorer small artery vascular reactivity in patients with increased CV risk.
    Thematic Areas: Administração pública e de empresas, ciências contábeis e turismo Biodiversidade Biotecnología Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Engenharias ii Engenharias iv Farmacia General medicine Interdisciplinar Matemática / probabilidade e estatística Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Nutrition & dietetics Nutrition and dietetics Odontología Química Saúde coletiva Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josefa.girona@urv.cat luis.masana@urv.cat nuria.plana@urv.cat josefa.girona@urv.cat daiana.ibarretxe@urv.cat
    ISSN: 14752662
    Author identifier: 0000-0002-6267-8779 0000-0002-0789-4954 0000-0002-4231-7618 0000-0002-6267-8779
    Record's date: 2023-02-26
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/negative-effect-of-a-lowcarbohydrate-highprotein-highfat-diet-on-small-peripheral-artery-reactivity-in-patients-with-increased-cardiovascular-risk/29A9DD30AC660BBDA5470D1E173C0E6F
    Papper original source: British Journal Of Nutrition. 109 (7): 1241-1247
    APA: IBARRECHE GUEREDIAGA, DAIANA; ARAGONÈS BARGALLÓ, GEMMA; Merino, Jordi; Kones, Richard; Ferre, Raimon; Plana, Nuria; Girona, Josefa; Aragones, Gemma; I (2013). Negative effect of a low-carbohydrate, high-protein, high-fat diet on small peripheral artery reactivity in patients with increased cardiovascular risk. British Journal Of Nutrition, 109(7), 1241-1247. DOI: 10.1017/S0007114512003091
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1017/S0007114512003091
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2013
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Abdominal obesity
    Adult
    Aged
    Cardiovascular risk
    Cohort studies
    Complications
    Cross-sectional relations
    Cross-sectional studies
    Diabetes mellitus, type 2
    Diet therapy
    Disease
    Endothelial function
    Endothelium, vascular
    Etiology
    Female
    Health
    Humans
    Life-style changes
    Low-carbohydrate diets
    Male
    Markers
    Metabolic syndrome
    Metabolic syndrome x
    Middle aged
    Overweight
    Risk factors
    Self care
    Spain
    Type 2 diabetes mellitus
    Vascular function
    Very-low-carbohydrate
    Weight-loss
    Administração pública e de empresas, ciências contábeis e turismo
    Biodiversidade
    Biotecnología
    Ciência de alimentos
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Educação física
    Engenharias ii
    Engenharias iv
    Farmacia
    General medicine
    Interdisciplinar
    Matemática / probabilidade e estatística
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Nutrição
    Nutrition & dietetics
    Nutrition and dietetics
    Odontología
    Química
    Saúde coletiva
    Zootecnia / recursos pesqueiros
    14752662
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