Articles producció científica> Bioquímica i Biotecnologia

Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters

  • Identification data

    Identifier: imarina:5671682
    Authors:
    Giardina, SimonaHernandez-Alonso, PabloSalas-Salvado, JordiRabassa-Soler, AntoniBullo, Monica
    Abstract:
    © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
  • Others:

    Author, as appears in the article.: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Rabassa Soler, Antonio / Salas Salvadó, Jorge
    Keywords: Waist circumference Transcriptome Subcutaneous fat Post-transcriptional regulation Overweight Obesity Micrornas Male Humans High-throughput Glycemic index Female Diet, fat-restricted Diet Carbohydrates Caloric restriction Body weight Adult Adiposity obesity high-throughput diet carbohydrates
    Abstract: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Author's mail: antonio.rabassa@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201700594
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Molecular Nutrition & Food Research. 62 (2): 1700594-
    APA: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica (2018). Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters. Molecular Nutrition & Food Research, 62(2), 1700594-. DOI: 10.1002/mnfr.201700594
    Article's DOI: 10.1002/mnfr.201700594
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Waist circumference
    Transcriptome
    Subcutaneous fat
    Post-transcriptional regulation
    Overweight
    Obesity
    Micrornas
    Male
    Humans
    High-throughput
    Glycemic index
    Female
    Diet, fat-restricted
    Diet
    Carbohydrates
    Caloric restriction
    Body weight
    Adult
    Adiposity
    obesity
    high-throughput
    diet
    carbohydrates
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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