Author, as appears in the article.: Livesey, Geoffrey; Taylor, Richard; Livesey, Helen F; Buyken, Anette E; Jenkins, David J A; Augustin, Livia S A; Sievenpiper, John L; Barclay, Alan W; Liu, Simin; Wolever, Thomas M S; Willett, Walter C; Brighenti, Furio; Salas-Salvado, Jordi; Bjorck, Inger; Rizkalla, Salwa W; Riccardi, Gabriele; Vecchia, Carlo La; Ceriello, Antonio; Trichopoulou, Antonia; Poli, Andrea; Astrup, Arne; Kendall, Cyril W C; Ha, Marie-Ann; Baer-Sinnott, Sara; Brand-Miller, Jennie C
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Type 2 diabetes Trend estimation Protein Population Meta?analysis Meta-analysis Mellitus Life-style Joint association Glycemic load Glycemic index Food-frequency questionnaire Fiber intake Epidemiology Dietary fiber Cohort studies Chronic disease Carbohydrate intake Alcohol intake Alcohol protein meta-analysis glycemic load glycemic index epidemiology dietary fiber cohort studies alcohol
Abstract: Published meta-analyses indicate significant but inconsistent incident type-2 diabetes(T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is nowover a decade ago that a published meta-analysis used a predefined standard to identify validstudies. Considering valid studies only, and using random effects dose-response meta-analysis(DRM) while withdrawing spurious results (p < 0.05), we ascertained whether these relationswould support nutrition guidance, specifically for an RR > 1.20 with a lower 95% confidence limit>1.10 across typical intakes (approximately 10th to 90th percentiles of population intakes). Thecombined T2D-GI RR was 1.27 (1.15-1.40) (p < 0.001, n = 10 studies) per 10 units GI, while that forthe T2D-GL RR was 1.26 (1.15-1.37) (p < 0.001, n = 15) per 80 g/d GL in a 2000 kcal (8400 kJ) diet.The corresponding global DRM using restricted cubic splines were 1.87 (1.56-2.25) (p < 0.001, n =10) and 1.89 (1.66-2.16) (p < 0.001, n = 15) from 47.6 to 76.1 units GI and 73 to 257 g/d GL in a 2000kcal diet, respectively. In conclusion, among adults initially in good health, diets higher in GI or GLwere robustly associated with incident T2D. Together with mechanistic and other data, thissupports that consideration should be given to these dietary risk factors in nutrition advice.Concerning the public health relevance at the global level, our evidence indicates that GI and GLare substantial food markers predicting the development of T2D worldwide, for persons ofEuropean ancestry and of East Asian ancestry.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 11 (6): 1280-
APA: Livesey, Geoffrey; Taylor, Richard; Livesey, Helen F; Buyken, Anette E; Jenkins, David J A; Augustin, Livia S A; Sievenpiper, John L; Barclay, Alan W; (2019). Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies. Nutrients, 11(6), 1280-. DOI: 10.3390/nu11061280
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV