Repositori URV

Author, as appears in the article.: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Aros, Fernando; Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Fiol, Miquel; Lapetra, Jose; Elosua, Roberto; Maria Lamuela-Raventos, Rosa; Fito, Montserrat

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Smoking habit Sex factors Sex factor Sex Risk factors Risk factor Protein function Prediction Oxidation Obesity Non insulin dependent diabetes mellitus Middle aged Male Major clinical study Low density lipoprotein cholesterol Low density lipoprotein Lipoproteins, ldl Lipoproteins, hdl Hypertension Humans Human High density lipoprotein cholesterol High density lipoprotein Framingham risk score Female Dyslipidemias Dyslipidemia Disease association Diabetes mellitus, type 2 Diabetes mellitus Cross-sectional study Cross-sectional studies Controlled study Complication Cholesterol, ldl Cholesterol, hdl Cholesterol Cardiovascular risk Cardiovascular diseases Cardiovascular disease Body mass Blood Atherosclerosis Article Aged Age factors Age Adult

Abstract: BACKGROUND: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. OBJECTIVE: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. METHODS: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. RESULTS: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). CONCLUSIONS: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.

Thematic Areas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2025-02-18

Paper version: info:eu-repo/semantics/publishedVersion

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Plos One. 14 (6): e0218533-

APA: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; (2019). Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. Plos One, 14(6), e0218533-. DOI: 10.1371/journal.pone.0218533

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications