Author, as appears in the article.: Hernáez Á; Soria-Florido MT; Schröder H; Ros E; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Arós F; Serra-Majem L; Martínez-González MÁ; Fiol M; Lapetra J; Elosua R; Lamuela-Raventós RM; Fitó M
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Adult Age Age factors Aged Article Atherosclerosis Blood Body mass Cardiovascular disease Cardiovascular diseases Cardiovascular risk Cholesterol Cholesterol, hdl Cholesterol, ldl Complication Controlled study Cross-sectional studies Cross-sectional study Diabetes mellitus Diabetes mellitus, type 2 Disease association Dyslipidemia Dyslipidemias Female Framingham risk score High density lipoprotein High density lipoprotein cholesterol Human Humans Hypertension Lipoproteins, hdl Lipoproteins, ldl Low density lipoprotein Low density lipoprotein cholesterol Major clinical study Male Middle aged Non insulin dependent diabetes mellitus Obesity Oxidation Prediction Protein function Risk factor Risk factors Sex Sex factor Sex factors Smoking habit
Abstract: BACKGROUND: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. OBJECTIVE: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. METHODS: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. RESULTS: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). CONCLUSIONS: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.
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licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
ISSN: 19326203
Author identifier: 0000-0003-2700-7459
Record's date: 2023-02-18
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218533
Papper original source: Plos One. 14 (6): e0218533-
APA: Hernáez Á; Soria-Florido MT; Schröder H; Ros E; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Arós F; Serra-Majem L; Martínez-González MÁ; Fiol M; L (2019). Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. Plos One, 14(6), e0218533-. DOI: 10.1371/journal.pone.0218533
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1371/journal.pone.0218533
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV