Articles producció científica> Bioquímica i Biotecnologia

Effects of a Mediterranean Eating Plan on the Need for Glucose-Lowering Medications in Participants With Type 2 Diabetes: A Subgroup Analysis of the PREDIMED Trial

  • Identification data

    Identifier: imarina:5779489
    Authors:
    Javier Basterra-Gortari, FRuiz-Canela, MiguelMartinez-Gonzalez, Miguel ABabio, NancySorli, Jose VFito, MontserratRos, EmilioGomez-Gracia, EnriqueFiol, MiquelLapetra, JoseEstruch, RamonSerra-Majem, LuisPinto, XavierGonzalez, Jose IBullo, MonicaCastaner, OlgaAlonso-Gomez, AngelForga, LuisAros, Fernando
    Abstract:
    OBJECTIVE To examine the effects of two Mediterranean eating plans (Med-EatPlans) versus a low-fat eating plan on the need for glucose-lowering medications. RESEARCH DESIGN AND METHODS From the Prevencion con Dieta Mediterranea (PREDIMED) trial, we selected 3,230 participants with type 2 diabetes at baseline. These participants were randomly assigned to one of three eating plans: Med-EatPlan supplemented with extra-virgin olive oil (EVOO), Med-EatPlan supplemented with mixed nuts, or a low-fat eating plan (control). In a subgroup (15%), the allocation was done in small clusters instead of using individual randomization, and the clustering effect was taken into account in the statistical analysis. In multivariable time-to-event survival models, we assessed two outcomes: 1) introduction of the first glucose-lowering medication (oral or injectable) among participants on lifestyle management at enrollment and 2) insulin initiation. RESULTS After a median follow-up of 3.2 years, in multivariable analyses adjusting for baseline characteristics and propensity scores, the hazard ratios (HRs) of starting a first glucose-lowering medication were 0.78 (95% CI 0.62-0.98) for Med-EatPlan + EVOO and 0.89 (0.71-1.12) for Med-EatPlan + nuts, compared with the control eating plan. After a median follow-up of 5.1 years, the adjusted HRs of starting insulin treatment were 0.87 (0.68-1.11) for Med-EatPlan + EVOO and 0.89 (0.69-1.14) for Med-EatPlan + nuts compared with the control eating plan. CONCLUSIONS Among participants with type 2 diabetes, a Med-EatPlan + EVOO may delay the introduction of new-onset glucose-lowering medications. The Med-EatPlan did not result in a significantly lower need for insulin.
  • Others:

    Author, as appears in the article.: Javier Basterra-Gortari, F; Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A; Babio, Nancy; Sorli, Jose V; Fito, Montserrat; Ros, Emilio; Gomez-Gracia, Enrique; Fiol, Miquel; Lapetra, Jose; Estruch, Ramon; Serra-Majem, Luis; Pinto, Xavier; Gonzalez, Jose I; Bullo, Monica; Castaner, Olga; Alonso-Gomez, Angel; Forga, Luis; Aros, Fernando
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica
    Keywords: Treatment outcome Proportional hazards models Propensity score Olive oil Multivariate analysis Middle aged Male Hypoglycemic agents Humans Female Diet, mediterranean Diet, fat-restricted Diabetes mellitus, type 2 Cardiovascular risk-factors Blood glucose Aged therapy style diet outcomes metformin mellitus low-carbohydrate intervention insulin adherence
    Abstract: OBJECTIVE To examine the effects of two Mediterranean eating plans (Med-EatPlans) versus a low-fat eating plan on the need for glucose-lowering medications. RESEARCH DESIGN AND METHODS From the Prevencion con Dieta Mediterranea (PREDIMED) trial, we selected 3,230 participants with type 2 diabetes at baseline. These participants were randomly assigned to one of three eating plans: Med-EatPlan supplemented with extra-virgin olive oil (EVOO), Med-EatPlan supplemented with mixed nuts, or a low-fat eating plan (control). In a subgroup (15%), the allocation was done in small clusters instead of using individual randomization, and the clustering effect was taken into account in the statistical analysis. In multivariable time-to-event survival models, we assessed two outcomes: 1) introduction of the first glucose-lowering medication (oral or injectable) among participants on lifestyle management at enrollment and 2) insulin initiation. RESULTS After a median follow-up of 3.2 years, in multivariable analyses adjusting for baseline characteristics and propensity scores, the hazard ratios (HRs) of starting a first glucose-lowering medication were 0.78 (95% CI 0.62-0.98) for Med-EatPlan + EVOO and 0.89 (0.71-1.12) for Med-EatPlan + nuts, compared with the control eating plan. After a median follow-up of 5.1 years, the adjusted HRs of starting insulin treatment were 0.87 (0.68-1.11) for Med-EatPlan + EVOO and 0.89 (0.69-1.14) for Med-EatPlan + nuts compared with the control eating plan. CONCLUSIONS Among participants with type 2 diabetes, a Med-EatPlan + EVOO may delay the introduction of new-onset glucose-lowering medications. The Med-EatPlan did not result in a significantly lower need for insulin.
    Thematic Areas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01495992
    Author's mail: monica.bullo@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0003-3527-5277
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://diabetesjournals.org/care/article/42/8/1390/36123/Effects-of-a-Mediterranean-Eating-Plan-on-the-Need
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Diabetes Care. 42 (8): 1390-1397
    APA: Javier Basterra-Gortari, F; Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A; Babio, Nancy; Sorli, Jose V; Fito, Montserrat; Ros, Emilio; Gomez-Gracia (2019). Effects of a Mediterranean Eating Plan on the Need for Glucose-Lowering Medications in Participants With Type 2 Diabetes: A Subgroup Analysis of the PREDIMED Trial. Diabetes Care, 42(8), 1390-1397. DOI: 10.2337/dc18-2475
    Article's DOI: 10.2337/dc18-2475
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Treatment outcome
    Proportional hazards models
    Propensity score
    Olive oil
    Multivariate analysis
    Middle aged
    Male
    Hypoglycemic agents
    Humans
    Female
    Diet, mediterranean
    Diet, fat-restricted
    Diabetes mellitus, type 2
    Cardiovascular risk-factors
    Blood glucose
    Aged
    therapy
    style diet
    outcomes
    metformin
    mellitus
    low-carbohydrate
    intervention
    insulin
    adherence
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing
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