Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author, as appears in the article.: Becerra-Tomas, Nerea; Mena-Sanchez, Guillermo; Diaz-Lopez, Andres; Angel Martinez-Gonzalez, Miguel; Babio, Nancy; Corella, Dolores; Freixer, Gala; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Alfredo Martinez, J; Serra-Majem, Lluis; Estruch, Ramon; Carlos Fernandez-Garcia, Jose; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Bueno-Cavanillas, Aurora; Juan Gaforio, Jose; Matia-Martin, Pilar; Daimiel, Lidia; Martin-Sanchez, Vicente; Vidal, Josep; Vazquez, Clotilde; Ros, Emili; Razquin, Cristina; Abellan Cano, Ivan; Sorli, Jose, V; Torres, Laura; Morey, Marga; Navarrete-Munoz, Eva Ma; Tojal Sierra, Lucas; Crespo-Oliva, Edelys; Angeles Zulet, M; Sanchez-Villegas, Almudena; Casas, Rosa; Rosa Bernal-Lopez, M; Manuel Santos-Lozano, Jose; Corbella, Emili; del Mar Bibiloni, Maria; Ruiz-Canela, Miguel; Fernandez-Carrion, Rebeca; Quifer, Mireia; Prieto, Rafel M; Fernandez-Brufal, Noelia; Salaverria Lete, Itziar; Carlos Cenoz, Juan; Llimona, Regina; Salas-Salvado, Jordi

Department: Bioquímica i Biotecnologia; Medicina i Cirurgia

URV's Author/s: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Díaz López, Andres / García Gavilán, Jesús Francisco / MENA SÁNCHEZ, GUILLERMO / Paz Graniel, Indira del Socorro / Salas Huetos, Albert / Salas Salvadó, Jorge

Keywords: Validation; Uric acid; Serum uric acid; Risk factors; Risk; Protein; Prevalence; Predimed-plus; Physical-activity questionnaire; Non-soy legumes; National-health; Metabolic syndrome; Mediterranean diet; Hyperuricemia; Humans; Gout; Fabaceae; Cross-sectional studies; Aged

Abstract: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. Methods: A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively. Results: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence. Conclusions: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence. Trial registration: ISRCTN89898870. Registration date: 24 July 2014.

Thematic Areas: Serviço social; Saúde coletiva; Química; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Farmacia; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14366207

Author's mail: jesusfrancisco.garcia@urv.cat; juanjose.cabre@urv.cat; indiradelsocorro.paz@urv.cat; josep.basora@urv.cat; andres.diaz@urv.cat; albert.salas@urv.cat; nerea.becerra@urv.cat; jesusfrancisco.garcia@urv.cat; indiradelsocorro.paz@urv.cat; monica.bullo@urv.cat; josep.basora@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat

Record's date: 2025-02-17

Paper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007/s00394-019-02070-w

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: European Journal Of Nutrition. 59 (5): 2195-2206

APA: Becerra-Tomas, Nerea; Mena-Sanchez, Guillermo; Diaz-Lopez, Andres; Angel Martinez-Gonzalez, Miguel; Babio, Nancy; Corella, Dolores; Freixer, Gala; Rom (2020). Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study. European Journal Of Nutrition, 59(5), 2195-2206. DOI: 10.1007/s00394-019-02070-w

Article's DOI: 10.1007/s00394-019-02070-w

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications