Author, as appears in the article.: Basaure P; Guardia-Escote L; Biosca-Brull J; Blanco J; Cabré M; Peris-Sampedro F; Sánchez-Santed F; Domingo JL; Colomina MT
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia
URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Keywords: Targeted replacement Social behavior Polymorphisms Pesticide exposure Oxytocin Level Insecticide chlorpyrifos Gene x environmental factor Feeding control Developmental exposure Chronic dietary Chlorpyrifos Apolipoprotein-e gene Apoe genotype Aggressive-behavior gene x environmental factor feeding control chlorpyrifos apoe genotype
Abstract: © 2019 Elsevier Inc. To date, we have shown that apolipoprotein E (APOE) polymorphisms differentially modulate the neurobehavioral and metabolic effects of chlorpyrifos (CPF), a widely used pesticide, which is detected as residue in food. We previously reported that, after being exposed to CPF, APOE3 subjects exhibit metabolic dysfunctions while APOE4 subjects undergo changes in behavior. In the current study, we investigated the effects of a double exposure to CPF on social behavior and hypothalamic gene expression in apoE-targeted replacement (TR) mice. Male apoE3-and apoE4-TR mice were exposed to CPF at 0 or 1 mg/kg/day on postnatal days 10–15 and then, during adulthood (5 months of age), fed a CPF-supplemented diet (0 or 2 mg/kg/day) for 15 days. During adult exposure to CPF, body weight gain and food intake were monitored. At the end of the adult exposure period, we evaluated social behavior in a three-chamber test, as well as mRNA levels of hypothalamic neuropeptides and receptors related to social behavior and feeding control. Adult CPF exposure increased food intake in general, but only apoE4 mice increased their body weight. Postnatal CPF exposure improved preference for the social contexts in apoE4 mice while adult CPF exposure did the same in apoE3 mice. Anorexigenic-peptide and social-related behavior gene expression decreased as a result of adult CPF exposure in apoE4 mice, and neuropeptide Y was more expressed in apoE4 mice. These results indicate that CPF exposure produces orexigenic and metabolic effects and enlarges individual differences in social behavior, especially in apoE3 mice.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00139351
Author's mail: jordi.blanco@urv.cat mariateresa.colomina@urv.cat joseluis.domingo@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat maria.cabre@urv.cat
Author identifier: 0000-0001-8016-0984 0000-0002-5619-4874 0000-0001-6647-9470 0000-0003-4124-8603
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0013935119304815?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Research. 178 (108684): 108684-
APA: Basaure P; Guardia-Escote L; Biosca-Brull J; Blanco J; Cabré M; Peris-Sampedro F; Sánchez-Santed F; Domingo JL; Colomina MT (2019). Exposure to chlorpyrifos at different ages triggers APOE genotype-specific responses in social behavior, body weight and hypothalamic gene expression. Environmental Research, 178(108684), 108684-. DOI: 10.1016/j.envres.2019.108684
Article's DOI: 10.1016/j.envres.2019.108684
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV